Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 15 studies | 35% ± 15% | |
| endothelial cell | 15 studies | 30% ± 13% | |
| microglial cell | 12 studies | 31% ± 11% | |
| oligodendrocyte precursor cell | 11 studies | 45% ± 14% | |
| pericyte | 10 studies | 32% ± 14% | |
| fibroblast | 9 studies | 28% ± 11% | |
| macrophage | 7 studies | 32% ± 10% | |
| oligodendrocyte | 7 studies | 25% ± 7% | |
| retinal ganglion cell | 6 studies | 38% ± 21% | |
| endothelial cell of lymphatic vessel | 6 studies | 48% ± 14% | |
| smooth muscle cell | 6 studies | 29% ± 6% | |
| epithelial cell | 5 studies | 29% ± 20% | |
| GABAergic neuron | 5 studies | 33% ± 12% | |
| glutamatergic neuron | 4 studies | 35% ± 10% | |
| granule cell | 4 studies | 43% ± 15% | |
| interneuron | 4 studies | 53% ± 15% | |
| amacrine cell | 4 studies | 39% ± 29% | |
| retinal cone cell | 4 studies | 41% ± 18% | |
| retinal rod cell | 4 studies | 31% ± 8% | |
| monocyte | 4 studies | 31% ± 8% | |
| club cell | 4 studies | 21% ± 7% | |
| type II pneumocyte | 4 studies | 24% ± 9% | |
| hepatic stellate cell | 3 studies | 27% ± 6% | |
| classical monocyte | 3 studies | 20% ± 4% | |
| neuron | 3 studies | 28% ± 8% | |
| progenitor cell | 3 studies | 41% ± 9% | |
| ciliated cell | 3 studies | 31% ± 6% | |
| OFF-bipolar cell | 3 studies | 47% ± 16% | |
| ON-bipolar cell | 3 studies | 55% ± 23% | |
| glycinergic amacrine cell | 3 studies | 46% ± 5% | |
| retina horizontal cell | 3 studies | 28% ± 13% | |
| retinal pigment epithelial cell | 3 studies | 32% ± 10% | |
| dendritic cell | 3 studies | 20% ± 3% | |
| ependymal cell | 3 studies | 45% ± 13% | |
| mast cell | 3 studies | 25% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 3733.75 | 180 / 180 | 100% | 16.68 | 428 / 430 |
| brain | 98% | 1090.09 | 2587 / 2642 | 100% | 17.10 | 703 / 705 |
| pancreas | 100% | 3136.51 | 328 / 328 | 96% | 12.29 | 171 / 178 |
| prostate | 99% | 1480.18 | 243 / 245 | 97% | 7.40 | 485 / 502 |
| lung | 100% | 1988.46 | 577 / 578 | 93% | 11.78 | 1072 / 1155 |
| skin | 98% | 1400.66 | 1769 / 1809 | 92% | 9.82 | 435 / 472 |
| kidney | 100% | 1217.69 | 89 / 89 | 90% | 7.07 | 808 / 901 |
| stomach | 100% | 1463.19 | 359 / 359 | 87% | 9.31 | 250 / 286 |
| esophagus | 93% | 945.29 | 1343 / 1445 | 90% | 13.39 | 165 / 183 |
| intestine | 100% | 1788.33 | 964 / 966 | 83% | 6.96 | 436 / 527 |
| thymus | 99% | 1286.34 | 649 / 653 | 81% | 5.96 | 491 / 605 |
| uterus | 99% | 1759.89 | 169 / 170 | 78% | 7.26 | 359 / 459 |
| breast | 100% | 2407.86 | 459 / 459 | 76% | 4.71 | 846 / 1118 |
| bladder | 100% | 3090.57 | 21 / 21 | 63% | 4.66 | 320 / 504 |
| adrenal gland | 90% | 561.06 | 231 / 258 | 44% | 2.35 | 101 / 230 |
| blood vessel | 100% | 2494.04 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1392.51 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2747.15 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 79% | 1365.17 | 735 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 4.04 | 32 / 45 |
| eye | 0% | 0 | 0 / 0 | 70% | 3.71 | 56 / 80 |
| heart | 60% | 371.49 | 514 / 861 | 0% | 0 | 0 / 0 |
| muscle | 55% | 304.92 | 443 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 1.48 | 10 / 29 |
| liver | 19% | 97.55 | 42 / 226 | 15% | 0.85 | 60 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008592 | Biological process | regulation of Toll signaling pathway |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0005829 | Cellular component | cytosol |
| GO_0034450 | Molecular function | ubiquitin-ubiquitin ligase activity |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PELI2 |
| Protein name | E3 ubiquitin-protein ligase pellino homolog (EC 2.3.2.27) E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2) Pellino E3 ubiquitin protein ligase family member 2 |
| Synonyms | |
| Description | FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. . FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. . |
| Accessions | ENST00000561019.1 H0YK56 A0A994J4T1 Q9HAT8 ENST00000705193.1 ENST00000559044.5 H0YNF4 ENST00000267460.9 |