PELI2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008592Biological processregulation of Toll signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0000209Biological processprotein polyubiquitination
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0005829Cellular componentcytosol
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePELI2
Protein nameE3 ubiquitin-protein ligase pellino homolog (EC 2.3.2.27)
E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)
Pellino E3 ubiquitin protein ligase family member 2
Synonyms
DescriptionFUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. .

FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. .

AccessionsENST00000561019.1
H0YK56
A0A994J4T1
Q9HAT8
ENST00000705193.1
ENST00000559044.5
H0YNF4
ENST00000267460.9