OTULIN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0050728Biological processnegative regulation of inflammatory response
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0006508Biological processproteolysis
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_1990108Biological processprotein linear deubiquitination
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0045087Biological processinnate immune response
GO_0002040Biological processsprouting angiogenesis
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071797Cellular componentLUBAC complex
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameOTULIN
Protein nameUbiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)
OTU deubiquitinase with linear linkage specificity
SynonymsFAM105B
DescriptionFUNCTION: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response . Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex . Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex . OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex . Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis . In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation . Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling . .

AccessionsENST00000284274.5
ENST00000506417.1
D6RD57
H0Y8S4
H0Y9T0
A0A8V8TKZ0
ENST00000514913.1
ENST00000503023.2
ENST00000697367.1
Q96BN8