Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 6 studies | 26% ± 5% | |
macrophage | 6 studies | 20% ± 5% | |
microglial cell | 5 studies | 24% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 24% ± 5% | |
epithelial cell | 4 studies | 24% ± 5% | |
astrocyte | 4 studies | 21% ± 4% | |
endothelial cell | 4 studies | 21% ± 4% | |
leukocyte | 3 studies | 23% ± 8% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 21% ± 3% | |
myeloid cell | 3 studies | 21% ± 5% | |
lymphocyte | 3 studies | 22% ± 4% | |
gamma-delta T cell | 3 studies | 23% ± 3% | |
mature NK T cell | 3 studies | 17% ± 2% | |
GABAergic neuron | 3 studies | 27% ± 9% | |
glutamatergic neuron | 3 studies | 33% ± 12% | |
oligodendrocyte precursor cell | 3 studies | 19% ± 2% | |
endothelial cell of lymphatic vessel | 3 studies | 19% ± 5% | |
plasmacytoid dendritic cell | 3 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1661.96 | 1445 / 1445 | 100% | 16.37 | 183 / 183 |
intestine | 100% | 1437.38 | 966 / 966 | 100% | 10.55 | 527 / 527 |
liver | 100% | 1968.58 | 226 / 226 | 100% | 9.51 | 406 / 406 |
lung | 100% | 2213.27 | 578 / 578 | 100% | 16.41 | 1155 / 1155 |
prostate | 100% | 2202.42 | 245 / 245 | 100% | 11.10 | 502 / 502 |
stomach | 100% | 1024.46 | 359 / 359 | 100% | 10.94 | 286 / 286 |
uterus | 100% | 1379.51 | 170 / 170 | 100% | 15.45 | 459 / 459 |
breast | 100% | 1584.28 | 459 / 459 | 100% | 12.27 | 1116 / 1118 |
bladder | 100% | 1456.71 | 21 / 21 | 99% | 12.40 | 501 / 504 |
thymus | 100% | 1438.87 | 652 / 653 | 99% | 7.13 | 601 / 605 |
kidney | 100% | 1270.07 | 89 / 89 | 99% | 10.67 | 892 / 901 |
ovary | 100% | 1477.66 | 180 / 180 | 99% | 6.43 | 424 / 430 |
pancreas | 100% | 868.61 | 327 / 328 | 99% | 9.85 | 176 / 178 |
skin | 100% | 3413.16 | 1809 / 1809 | 99% | 11.25 | 465 / 472 |
brain | 96% | 691.64 | 2529 / 2642 | 100% | 6.73 | 705 / 705 |
adrenal gland | 100% | 1120.97 | 258 / 258 | 95% | 5.65 | 219 / 230 |
adipose | 100% | 1594.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 33.62 | 29 / 29 |
spleen | 100% | 1823.90 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.47 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.56 | 1 / 1 |
blood vessel | 100% | 1888.27 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1057.61 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1253.34 | 843 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 1929.61 | 899 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 83% | 4.00 | 66 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070431 | Biological process | nucleotide-binding oligomerization domain containing 2 signaling pathway |
GO_0016567 | Biological process | protein ubiquitination |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0050728 | Biological process | negative regulation of inflammatory response |
GO_0010803 | Biological process | regulation of tumor necrosis factor-mediated signaling pathway |
GO_0006508 | Biological process | proteolysis |
GO_0060828 | Biological process | regulation of canonical Wnt signaling pathway |
GO_1990108 | Biological process | protein linear deubiquitination |
GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
GO_0045087 | Biological process | innate immune response |
GO_0002040 | Biological process | sprouting angiogenesis |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0071797 | Cellular component | LUBAC complex |
GO_0008234 | Molecular function | cysteine-type peptidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
Gene name | OTULIN |
Protein name | Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) OTU deubiquitinase with linear linkage specificity |
Synonyms | FAM105B |
Description | FUNCTION: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response . Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex . Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex . OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex . Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis . In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation . Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling . . |
Accessions | ENST00000284274.5 ENST00000506417.1 D6RD57 H0Y8S4 H0Y9T0 A0A8V8TKZ0 ENST00000514913.1 ENST00000503023.2 ENST00000697367.1 Q96BN8 |