NSMCE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0032204Biological processregulation of telomere maintenance
GO_0045842Biological processpositive regulation of mitotic metaphase/anaphase transition
GO_0051301Biological processcell division
GO_0000722Biological processtelomere maintenance via recombination
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0034184Biological processpositive regulation of maintenance of mitotic sister chromatid cohesion
GO_0140588Biological processchromatin looping
GO_0090398Biological processcellular senescence
GO_0005654Cellular componentnucleoplasm
GO_0030915Cellular componentSmc5-Smc6 complex
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0019789Molecular functionSUMO transferase activity
GO_0061665Molecular functionSUMO ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNSMCE2
Protein nameNSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
E3 SUMO-protein ligase NSE2 (E3 SUMO-protein transferase NSE2) (Non-structural maintenance of chromosomes element 2 homolog)
E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)
SynonymsMMS21
C8orf36
DescriptionFUNCTION: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination . Is not be required for the stability of the complex . The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks . The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 . Required for recruitment of telomeres to PML nuclear bodies . SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines . Required for sister chromatid cohesion during prometaphase and mitotic progression . .

AccessionsE5RFJ1
E5RG00
ENST00000517532.5
ENST00000523741.5
H0YB96
A0A087WTZ8
ENST00000520866.5
E5RIM1
ENST00000517315.1
E5RK09
ENST00000519712.1
ENST00000522563.5
E5RHW9
ENST00000518146.5
ENST00000518013.5
ENST00000519010.5
ENST00000287437.8
Q96MF7