Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 38% ± 13% | |
astrocyte | 18 studies | 40% ± 19% | |
oligodendrocyte | 15 studies | 54% ± 16% | |
microglial cell | 15 studies | 46% ± 13% | |
fibroblast | 14 studies | 33% ± 11% | |
oligodendrocyte precursor cell | 13 studies | 37% ± 15% | |
macrophage | 13 studies | 40% ± 16% | |
glutamatergic neuron | 11 studies | 47% ± 26% | |
pericyte | 11 studies | 32% ± 10% | |
GABAergic neuron | 10 studies | 44% ± 23% | |
smooth muscle cell | 10 studies | 30% ± 10% | |
myeloid cell | 9 studies | 31% ± 13% | |
adipocyte | 9 studies | 50% ± 11% | |
mast cell | 8 studies | 26% ± 10% | |
epithelial cell | 7 studies | 41% ± 15% | |
B cell | 7 studies | 23% ± 7% | |
ciliated cell | 7 studies | 26% ± 9% | |
endothelial cell of lymphatic vessel | 7 studies | 41% ± 10% | |
neuron | 6 studies | 45% ± 26% | |
interneuron | 6 studies | 47% ± 24% | |
dendritic cell | 6 studies | 29% ± 3% | |
T cell | 6 studies | 29% ± 9% | |
type I pneumocyte | 6 studies | 36% ± 10% | |
type II pneumocyte | 6 studies | 40% ± 12% | |
retinal ganglion cell | 5 studies | 35% ± 15% | |
retinal cone cell | 5 studies | 33% ± 11% | |
cardiac muscle cell | 5 studies | 41% ± 9% | |
monocyte | 5 studies | 44% ± 12% | |
club cell | 5 studies | 34% ± 13% | |
natural killer cell | 5 studies | 25% ± 6% | |
basal cell | 5 studies | 37% ± 18% | |
glial cell | 4 studies | 30% ± 7% | |
granule cell | 4 studies | 32% ± 6% | |
plasma cell | 4 studies | 32% ± 3% | |
retinal pigment epithelial cell | 4 studies | 50% ± 22% | |
mesothelial cell | 4 studies | 35% ± 8% | |
lymphocyte | 4 studies | 29% ± 11% | |
Mueller cell | 4 studies | 35% ± 8% | |
amacrine cell | 4 studies | 32% ± 3% | |
retina horizontal cell | 4 studies | 33% ± 6% | |
retinal rod cell | 4 studies | 42% ± 13% | |
GABAergic interneuron | 3 studies | 33% ± 4% | |
CD4-positive, alpha-beta T cell | 3 studies | 23% ± 3% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 5% | |
mononuclear phagocyte | 3 studies | 31% ± 11% | |
vein endothelial cell | 3 studies | 31% ± 16% | |
GABAergic amacrine cell | 3 studies | 33% ± 7% | |
OFF-bipolar cell | 3 studies | 34% ± 9% | |
ON-bipolar cell | 3 studies | 33% ± 8% | |
glycinergic amacrine cell | 3 studies | 27% ± 2% | |
endothelial cell of vascular tree | 3 studies | 33% ± 8% | |
hepatocyte | 3 studies | 60% ± 19% | |
ependymal cell | 3 studies | 39% ± 15% | |
leukocyte | 3 studies | 34% ± 14% | |
alveolar macrophage | 3 studies | 58% ± 11% | |
capillary endothelial cell | 3 studies | 29% ± 3% | |
respiratory goblet cell | 3 studies | 40% ± 16% | |
transit amplifying cell | 3 studies | 42% ± 32% | |
mural cell | 3 studies | 38% ± 4% | |
mucus secreting cell | 3 studies | 32% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 860.73 | 459 / 459 | 100% | 32.51 | 1118 / 1118 |
esophagus | 100% | 753.54 | 1445 / 1445 | 100% | 18.82 | 183 / 183 |
lung | 100% | 710.64 | 578 / 578 | 100% | 24.21 | 1155 / 1155 |
ovary | 100% | 763.52 | 180 / 180 | 100% | 26.94 | 430 / 430 |
stomach | 100% | 620.53 | 359 / 359 | 100% | 21.87 | 286 / 286 |
uterus | 100% | 715.83 | 170 / 170 | 100% | 26.45 | 459 / 459 |
thymus | 100% | 655.49 | 653 / 653 | 100% | 21.43 | 604 / 605 |
intestine | 100% | 743.34 | 966 / 966 | 100% | 21.68 | 526 / 527 |
bladder | 100% | 760.05 | 21 / 21 | 100% | 24.75 | 503 / 504 |
prostate | 100% | 634.06 | 245 / 245 | 100% | 19.80 | 501 / 502 |
kidney | 100% | 628.54 | 89 / 89 | 99% | 16.21 | 896 / 901 |
liver | 100% | 328.06 | 225 / 226 | 100% | 21.41 | 405 / 406 |
pancreas | 99% | 338.47 | 326 / 328 | 99% | 18.49 | 177 / 178 |
brain | 99% | 393.72 | 2610 / 2642 | 100% | 15.45 | 705 / 705 |
adrenal gland | 100% | 832.49 | 258 / 258 | 99% | 17.83 | 227 / 230 |
skin | 100% | 756.65 | 1809 / 1809 | 99% | 25.49 | 465 / 472 |
adipose | 100% | 840.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 32.39 | 29 / 29 |
muscle | 100% | 907.11 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 665.05 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 23.51 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.51 | 1 / 1 |
blood vessel | 100% | 841.86 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 613.90 | 843 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 34.55 | 77 / 80 |
peripheral blood | 85% | 456.32 | 791 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016925 | Biological process | protein sumoylation |
GO_0006303 | Biological process | double-strand break repair via nonhomologous end joining |
GO_0032204 | Biological process | regulation of telomere maintenance |
GO_0045842 | Biological process | positive regulation of mitotic metaphase/anaphase transition |
GO_0051301 | Biological process | cell division |
GO_0000722 | Biological process | telomere maintenance via recombination |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0034184 | Biological process | positive regulation of maintenance of mitotic sister chromatid cohesion |
GO_0140588 | Biological process | chromatin looping |
GO_0090398 | Biological process | cellular senescence |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030915 | Cellular component | Smc5-Smc6 complex |
GO_0016604 | Cellular component | nuclear body |
GO_0016605 | Cellular component | PML body |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005634 | Cellular component | nucleus |
GO_0019789 | Molecular function | SUMO transferase activity |
GO_0061665 | Molecular function | SUMO ligase activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NSMCE2 |
Protein name | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase E3 SUMO-protein ligase NSE2 (E3 SUMO-protein transferase NSE2) (Non-structural maintenance of chromosomes element 2 homolog) E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) |
Synonyms | MMS21 C8orf36 |
Description | FUNCTION: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination . Is not be required for the stability of the complex . The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks . The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 . Required for recruitment of telomeres to PML nuclear bodies . SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines . Required for sister chromatid cohesion during prometaphase and mitotic progression . . |
Accessions | E5RFJ1 E5RG00 ENST00000517532.5 ENST00000523741.5 H0YB96 A0A087WTZ8 ENST00000520866.5 E5RIM1 ENST00000517315.1 E5RK09 ENST00000519712.1 ENST00000522563.5 E5RHW9 ENST00000518146.5 ENST00000518013.5 ENST00000519010.5 ENST00000287437.8 Q96MF7 |