NFATC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NFATC1 at tissue level.

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0043501Biological processskeletal muscle adaptation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001816Biological processcytokine production
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0003180Biological processaortic valve morphogenesis
GO_0014850Biological processresponse to muscle activity
GO_1905064Biological processnegative regulation of vascular associated smooth muscle cell differentiation
GO_0042060Biological processwound healing
GO_1903131Biological processmononuclear cell differentiation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0035556Biological processintracellular signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000573Biological processpositive regulation of DNA biosynthetic process
GO_0003184Biological processpulmonary valve morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016528Cellular componentsarcoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0048273Molecular functionmitogen-activated protein kinase p38 binding
GO_0003676Molecular functionnucleic acid binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0001223Molecular functiontranscription coactivator binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005528Molecular functionFK506 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFATC1
Protein nameNuclear factor of activated T cells 1
Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)
Alternative protein NFATC1
SynonymsNFAT2
NFATC
DescriptionFUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells . Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). .

AccessionsO95644
ENST00000545796.5
ENST00000329101.8 [O95644-6]
ENST00000318065.9 [O95644-5]
ENST00000542384.5 [O95644-10]
ENST00000587635.5
ENST00000590313.5
K7ER53
K7EQ04
F5H4S8
ENST00000427363.7 [O95644-1]
ENST00000591814.5 [O95644-2]
ENST00000586434.1 [O95644-11]
L8ECN7
ENST00000397790.6 [O95644-17]
ENST00000592223.5 [O95644-3]
ENST00000253506.9 [O95644-4]