NELFCD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	9 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	7 studies	22% ± 5%	Explore
endothelial cell	7 studies	26% ± 10%	Explore
epithelial cell	7 studies	31% ± 16%	Explore
myofibroblast cell	6 studies	19% ± 2%	Explore
fibroblast	6 studies	19% ± 4%	Explore
neuron	6 studies	27% ± 12%	Explore
B cell	5 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
pericyte	5 studies	20% ± 6%	Explore
naive B cell	5 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
ciliated cell	4 studies	24% ± 8%	Explore
astrocyte	4 studies	20% ± 2%	Explore
abnormal cell	4 studies	23% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 7%	Explore
gamma-delta T cell	4 studies	25% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 3%	Explore
exhausted T cell	3 studies	25% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	20% ± 5%	Explore
non-classical monocyte	3 studies	23% ± 6%	Explore
T cell	3 studies	20% ± 4%	Explore
neural crest cell	3 studies	18% ± 1%	Explore
retinal bipolar neuron	3 studies	26% ± 7%	Explore
smooth muscle cell	3 studies	19% ± 4%	Explore
retina horizontal cell	3 studies	26% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	17% ± 3%	Explore
regulatory T cell	3 studies	18% ± 3%	Explore
glutamatergic neuron	3 studies	36% ± 14%	Explore
dendritic cell	3 studies	31% ± 13%	Explore
basal cell	3 studies	32% ± 8%	Explore
transit amplifying cell	3 studies	26% ± 8%	Explore
oligodendrocyte	3 studies	20% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 3%	Explore
double negative thymocyte	3 studies	26% ± 13%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	21% ± 5%	Explore
brain	4 studies	27% ± 9%	Explore
peripheral blood	3 studies	25% ± 6%	Explore
eye	3 studies	21% ± 3%	Explore
liver	3 studies	30% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3559.80	1445 / 1445	100%	58.69	183 / 183
liver	100%	2653.84	226 / 226	100%	39.45	406 / 406
lung	100%	3080.31	578 / 578	100%	56.35	1155 / 1155
ovary	100%	4861.67	180 / 180	100%	61.41	430 / 430
prostate	100%	4194.29	245 / 245	100%	52.65	502 / 502
skin	100%	4421.41	1809 / 1809	100%	72.54	472 / 472
stomach	100%	2661.16	359 / 359	100%	72.29	286 / 286
brain	100%	3177.40	2638 / 2642	100%	52.28	705 / 705
breast	100%	4186.74	459 / 459	100%	68.27	1116 / 1118
bladder	100%	3896.76	21 / 21	100%	68.41	503 / 504
uterus	100%	4274.19	170 / 170	100%	60.77	458 / 459
thymus	100%	5865.47	653 / 653	100%	42.66	603 / 605
intestine	100%	3546.56	966 / 966	99%	74.14	524 / 527
kidney	100%	3825.40	89 / 89	99%	39.80	895 / 901
adrenal gland	100%	4459.49	258 / 258	99%	35.39	228 / 230
pancreas	100%	2129.19	328 / 328	99%	40.59	176 / 178
adipose	100%	3538.96	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	81.16	80 / 80
lymph node	0%	0	0 / 0	100%	48.94	29 / 29
muscle	100%	2736.50	803 / 803	0%	0	0 / 0
spleen	100%	4603.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	49.85	45 / 45
ureter	0%	0	0 / 0	100%	42.53	1 / 1
blood vessel	100%	2972.91	1334 / 1335	0%	0	0 / 0
heart	98%	1856.50	845 / 861	0%	0	0 / 0
peripheral blood	89%	2160.99	824 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034244	Biological process	negative regulation of transcription elongation by RNA polymerase II
GO_0032021	Cellular component	NELF complex
GO_0005654	Cellular component	nucleoplasm
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	NELFCD
Protein name	Negative elongation factor complex member C/D (TH1-like (Drosophila), isoform CRA_b) Negative elongation factor complex member C/D Negative elongation factor C/D (NELF-C/D) (TH1-like protein)
Synonyms	TH1 NELFD hCG_28547 HSPC130 TH1L
Description	FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . .; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. .
Accessions	ENST00000652272.2 [Q8IXH7-4] Q8IXH7 ENST00000460601.5 H0UI80 X6RLT1 ENST00000602795.6

NELFCD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review