NARS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	13 studies	38% ± 14%	Explore
endothelial cell	13 studies	26% ± 11%	Explore
smooth muscle cell	12 studies	19% ± 4%	Explore
macrophage	12 studies	23% ± 9%	Explore
classical monocyte	11 studies	21% ± 8%	Explore
pericyte	11 studies	21% ± 5%	Explore
fibroblast	9 studies	26% ± 12%	Explore
basal cell	9 studies	29% ± 14%	Explore
epithelial cell	8 studies	41% ± 20%	Explore
natural killer cell	7 studies	17% ± 2%	Explore
endothelial cell of lymphatic vessel	7 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 9%	Explore
myofibroblast cell	6 studies	20% ± 4%	Explore
monocyte	6 studies	22% ± 5%	Explore
alveolar macrophage	5 studies	17% ± 2%	Explore
conventional dendritic cell	5 studies	29% ± 15%	Explore
epithelial cell of proximal tubule	5 studies	28% ± 5%	Explore
kidney loop of Henle epithelial cell	5 studies	32% ± 8%	Explore
connective tissue cell	5 studies	23% ± 6%	Explore
astrocyte	5 studies	25% ± 11%	Explore
glutamatergic neuron	5 studies	43% ± 22%	Explore
deuterosomal cell	4 studies	23% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
capillary endothelial cell	4 studies	18% ± 2%	Explore
retinal ganglion cell	4 studies	73% ± 22%	Explore
amacrine cell	4 studies	35% ± 15%	Explore
retina horizontal cell	4 studies	36% ± 11%	Explore
microglial cell	4 studies	22% ± 5%	Explore
secretory cell	4 studies	29% ± 15%	Explore
GABAergic neuron	4 studies	43% ± 10%	Explore
goblet cell	4 studies	26% ± 7%	Explore
transit amplifying cell	4 studies	24% ± 5%	Explore
oligodendrocyte	4 studies	21% ± 5%	Explore
mast cell	3 studies	20% ± 1%	Explore
type I pneumocyte	3 studies	24% ± 9%	Explore
ionocyte	3 studies	32% ± 7%	Explore
naive B cell	3 studies	17% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
non-classical monocyte	3 studies	26% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 5%	Explore
T cell	3 studies	19% ± 2%	Explore
neuron	3 studies	36% ± 7%	Explore
retinal bipolar neuron	3 studies	31% ± 10%	Explore
placental villous trophoblast	3 studies	23% ± 5%	Explore
myeloid cell	3 studies	34% ± 7%	Explore
club cell	3 studies	26% ± 7%	Explore
retinal cone cell	3 studies	37% ± 9%	Explore
retinal rod cell	3 studies	25% ± 9%	Explore
Mueller cell	3 studies	26% ± 4%	Explore
endothelial cell of artery	3 studies	16% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 4%	Explore
vein endothelial cell	3 studies	16% ± 0%	Explore
endothelial cell of vascular tree	3 studies	18% ± 3%	Explore
CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
abnormal cell	3 studies	26% ± 5%	Explore
interneuron	3 studies	37% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	29% ± 11%	Explore
eye	6 studies	26% ± 10%	Explore
brain	6 studies	34% ± 13%	Explore
peripheral blood	5 studies	21% ± 5%	Explore
intestine	5 studies	21% ± 9%	Explore
kidney	4 studies	22% ± 3%	Explore
placenta	3 studies	17% ± 1%	Explore
liver	3 studies	36% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7233.92	1445 / 1445	100%	126.30	183 / 183
intestine	100%	7647.36	966 / 966	100%	123.66	527 / 527
ovary	100%	5120.53	180 / 180	100%	105.38	430 / 430
prostate	100%	6216.85	245 / 245	100%	124.49	502 / 502
stomach	100%	6830.72	359 / 359	100%	127.65	286 / 286
breast	100%	6741.53	459 / 459	100%	159.99	1117 / 1118
kidney	100%	7317.40	89 / 89	100%	133.17	900 / 901
brain	100%	7262.71	2638 / 2642	100%	149.13	705 / 705
lung	100%	6471.38	577 / 578	100%	123.76	1155 / 1155
thymus	100%	7310.31	653 / 653	100%	141.74	603 / 605
bladder	100%	7348.52	21 / 21	100%	122.13	502 / 504
skin	100%	8741.01	1809 / 1809	100%	169.62	470 / 472
uterus	100%	6099.63	170 / 170	100%	124.49	457 / 459
pancreas	100%	3927.14	327 / 328	99%	89.47	177 / 178
adrenal gland	100%	7790.44	258 / 258	99%	102.70	228 / 230
liver	100%	3888.00	225 / 226	98%	82.02	399 / 406
adipose	100%	6706.29	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6891.10	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	127.08	80 / 80
lymph node	0%	0	0 / 0	100%	105.51	29 / 29
muscle	100%	8714.25	803 / 803	0%	0	0 / 0
spleen	100%	5525.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	122.60	45 / 45
ureter	0%	0	0 / 0	100%	35.92	1 / 1
heart	96%	5827.52	823 / 861	0%	0	0 / 0
peripheral blood	78%	3240.98	724 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0021987	Biological process	cerebral cortex development
GO_0016477	Biological process	cell migration
GO_0006418	Biological process	tRNA aminoacylation for protein translation
GO_0006421	Biological process	asparaginyl-tRNA aminoacylation
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0031728	Molecular function	CCR3 chemokine receptor binding
GO_0046983	Molecular function	protein dimerization activity
GO_0005515	Molecular function	protein binding
GO_0003676	Molecular function	nucleic acid binding
GO_0005524	Molecular function	ATP binding
GO_0004816	Molecular function	asparagine-tRNA ligase activity

IV. Literature review

[source]

Gene name	NARS1
Protein name	Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1) Asparaginyl-tRNA synthetase 1
Synonyms	NRS NARS
Description	FUNCTION: Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) . In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells . Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells . .
Accessions	O43776 K7EMQ6 K7EJ19 K7ENF0 K7EQ35 ENST00000591599.5 ENST00000587194.1 ENST00000588661.5 K7EIU7 ENST00000587675.5 ENST00000540592.5 [O43776-2] ENST00000586807.5 ENST00000590123.1 K7EPK2 ENST00000256854.10 [O43776-1]

NARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review