MYO1E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0001701Biological processin utero embryonic development
GO_0003094Biological processglomerular filtration
GO_0001570Biological processvasculogenesis
GO_0032836Biological processglomerular basement membrane development
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0035166Biological processpost-embryonic hemopoiesis
GO_0007015Biological processactin filament organization
GO_0072015Biological processpodocyte development
GO_0032835Biological processglomerulus development
GO_0005903Cellular componentbrush border
GO_0005902Cellular componentmicrovillus
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0032437Cellular componentcuticular plate
GO_0015629Cellular componentactin cytoskeleton
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0016459Cellular componentmyosin complex
GO_0051015Molecular functionactin filament binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMYO1E
Protein nameMYO1E variant protein (Myosin IE)
Myosin IE
Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)
SynonymshCG_38672
MYO1C
DescriptionFUNCTION: Actin-based motor molecule with ATPase activity . Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles . Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. .

AccessionsH0YNB0
H0YLJ4
ENST00000559269.5
ENST00000558571.1
Q4KMR3
ENST00000559412.1
H0YNQ8
Q12965
ENST00000288235.9
H0YLE5
H0YN00
ENST00000559489.1
ENST00000560749.1