MTHFD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	20 studies	34% ± 13%	Explore
conventional dendritic cell	19 studies	27% ± 11%	Explore
smooth muscle cell	18 studies	37% ± 13%	Explore
macrophage	17 studies	24% ± 6%	Explore
non-classical monocyte	16 studies	25% ± 7%	Explore
dendritic cell	15 studies	36% ± 15%	Explore
regulatory T cell	15 studies	28% ± 13%	Explore
classical monocyte	14 studies	21% ± 6%	Explore
monocyte	12 studies	25% ± 6%	Explore
plasma cell	11 studies	31% ± 14%	Explore
T cell	9 studies	21% ± 7%	Explore
CD4-positive, alpha-beta T cell	9 studies	35% ± 21%	Explore
CD8-positive, alpha-beta T cell	9 studies	33% ± 16%	Explore
natural killer cell	8 studies	25% ± 12%	Explore
fibroblast	8 studies	23% ± 6%	Explore
plasmablast	7 studies	37% ± 23%	Explore
myeloid cell	7 studies	28% ± 8%	Explore
mast cell	7 studies	34% ± 18%	Explore
hematopoietic precursor cell	5 studies	23% ± 4%	Explore
mononuclear phagocyte	5 studies	28% ± 7%	Explore
B cell	5 studies	22% ± 6%	Explore
connective tissue cell	5 studies	26% ± 9%	Explore
gamma-delta T cell	5 studies	22% ± 10%	Explore
erythroblast	4 studies	29% ± 11%	Explore
microglial cell	4 studies	25% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 7%	Explore
leukocyte	4 studies	24% ± 8%	Explore
endothelial cell of vascular tree	4 studies	23% ± 6%	Explore
T follicular helper cell	4 studies	30% ± 11%	Explore
plasmacytoid dendritic cell	4 studies	25% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	27% ± 9%	Explore
endothelial cell	3 studies	25% ± 8%	Explore
epithelial cell	3 studies	28% ± 5%	Explore
germinal center B cell	3 studies	24% ± 4%	Explore
exhausted T cell	3 studies	22% ± 9%	Explore
IgA plasma cell	3 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 13%	Explore
goblet cell	3 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	22% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	33% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	25% ± 9%	Explore
mature NK T cell	3 studies	16% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	22% ± 8%	Explore
uterus	3 studies	21% ± 7%	Explore
lymph node	3 studies	18% ± 2%	Explore
breast	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4115.71	457 / 459	100%	25.80	1114 / 1118
uterus	98%	3636.86	167 / 170	99%	22.48	456 / 459
lung	98%	3609.13	568 / 578	99%	24.07	1143 / 1155
stomach	97%	2566.33	350 / 359	100%	18.24	285 / 286
pancreas	100%	2938.79	327 / 328	96%	10.50	171 / 178
esophagus	94%	2347.26	1359 / 1445	99%	21.15	181 / 183
prostate	95%	2274.13	232 / 245	98%	12.08	491 / 502
intestine	89%	1947.13	862 / 966	98%	21.06	518 / 527
bladder	95%	3995.67	20 / 21	92%	18.11	463 / 504
skin	96%	3826.43	1730 / 1809	91%	13.70	431 / 472
ovary	72%	1584.67	130 / 180	100%	24.56	430 / 430
thymus	95%	2353.68	620 / 653	46%	3.52	276 / 605
brain	26%	419.00	688 / 2642	96%	22.98	674 / 705
kidney	67%	1508.02	60 / 89	49%	4.24	438 / 901
adrenal gland	43%	585.03	111 / 258	73%	6.20	167 / 230
blood vessel	100%	9520.81	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	35.92	29 / 29
tonsil	0%	0	0 / 0	100%	18.48	45 / 45
adipose	100%	4619.74	1200 / 1204	0%	0	0 / 0
spleen	100%	2476.34	240 / 241	0%	0	0 / 0
muscle	91%	3154.91	732 / 803	0%	0	0 / 0
heart	82%	1592.76	708 / 861	0%	0	0 / 0
peripheral blood	65%	3930.98	607 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	49%	3.46	39 / 80
liver	6%	80.52	14 / 226	7%	0.59	29 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0046655	Biological process	folic acid metabolic process
GO_0046653	Biological process	tetrahydrofolate metabolic process
GO_0035999	Biological process	tetrahydrofolate interconversion
GO_0005615	Cellular component	extracellular space
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0004477	Molecular function	methenyltetrahydrofolate cyclohydrolase activity
GO_0004487	Molecular function	methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO_0042301	Molecular function	phosphate ion binding
GO_0004488	Molecular function	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO_0005515	Molecular function	protein binding
GO_0000287	Molecular function	magnesium ion binding

IV. Literature review

[source]

Gene name	MTHFD2
Protein name	methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Synonyms	NMDMC
Description	FUNCTION: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. .
Accessions	ENST00000677377.1 ENST00000678228.1 ENST00000678633.1 ENST00000678340.1 B9A062 ENST00000678684.1 [P13995-2] A0A7I2V482 ENST00000394053.7 [P13995-1] F8WF89 ENST00000678623.1 [P13995-2] ENST00000677997.1 A0A7I2YQD4 B8ZZU9 ENST00000679055.1 [P13995-2] ENST00000678731.1 [P13995-2] A0A7I2V2G4 A0A7I2V3T1 F8WF06 ENST00000462026.2 P13995 ENST00000489041.2 ENST00000409804.5 A0A7I2V2U6 ENST00000470592.5 ENST00000409601.1 ENST00000677170.1 [P13995-2] ENST00000677558.1

MTHFD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review