MLLT10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0031491Molecular functionnucleosome binding
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMLLT10
Protein nameProtein AF-10 (ALL1-fused gene from chromosome 10 protein)
MLLT10 histone lysine methyltransferase DOT1L cofactor
SynonymsAF10
DescriptionFUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation . .

AccessionsENST00000377072.8 [P55197-1]
ENST00000430455.2
ENST00000650772.1
ENST00000495130.5
Q5JT35
ENST00000377091.7 [P55197-2]
ENST00000462999.5
A0A494C0R2
H0Y5C4
ENST00000307729.12 [P55197-4]
A0A494C1P9
P55197
ENST00000377100.8 [P55197-3]
ENST00000438473.6
ENST00000650893.1
A0A494C038
ENST00000651097.1
H0Y5P4
ENST00000652497.1 [P55197-3]
ENST00000377059.7 [P55197-4]
ENST00000621220.4 [P55197-2]
ENST00000631589.1 [P55197-4]
A0A494C093
ENST00000420525.1
ENST00000651298.1