MKRN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	18 studies	22% ± 6%	Explore
natural killer cell	18 studies	21% ± 5%	Explore
non-classical monocyte	13 studies	33% ± 18%	Explore
classical monocyte	12 studies	28% ± 14%	Explore
memory B cell	12 studies	18% ± 2%	Explore
ciliated cell	11 studies	27% ± 12%	Explore
T cell	10 studies	18% ± 3%	Explore
erythrocyte	10 studies	51% ± 13%	Explore
regulatory T cell	9 studies	20% ± 4%	Explore
epithelial cell	9 studies	39% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 3%	Explore
CD4-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
macrophage	8 studies	21% ± 5%	Explore
endothelial cell	8 studies	23% ± 7%	Explore
platelet	7 studies	25% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	24% ± 5%	Explore
goblet cell	7 studies	28% ± 12%	Explore
smooth muscle cell	7 studies	21% ± 5%	Explore
fibroblast	7 studies	20% ± 4%	Explore
gamma-delta T cell	7 studies	22% ± 11%	Explore
conventional dendritic cell	6 studies	32% ± 20%	Explore
pericyte	6 studies	21% ± 7%	Explore
basal cell	6 studies	31% ± 14%	Explore
monocyte	6 studies	23% ± 4%	Explore
secretory cell	5 studies	21% ± 3%	Explore
mature NK T cell	5 studies	17% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
myofibroblast cell	5 studies	20% ± 4%	Explore
naive B cell	5 studies	19% ± 3%	Explore
CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 3%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
retina horizontal cell	4 studies	38% ± 14%	Explore
innate lymphoid cell	4 studies	19% ± 3%	Explore
GABAergic neuron	4 studies	33% ± 10%	Explore
glutamatergic neuron	4 studies	42% ± 13%	Explore
T follicular helper cell	4 studies	18% ± 2%	Explore
mast cell	4 studies	20% ± 3%	Explore
neuron	4 studies	33% ± 15%	Explore
respiratory goblet cell	3 studies	23% ± 8%	Explore
squamous epithelial cell	3 studies	38% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 1%	Explore
connective tissue cell	3 studies	23% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	16% ± 1%	Explore
leukocyte	3 studies	16% ± 1%	Explore
retinal ganglion cell	3 studies	62% ± 25%	Explore
megakaryocyte	3 studies	36% ± 11%	Explore
precursor B cell	3 studies	27% ± 7%	Explore
myeloid cell	3 studies	27% ± 8%	Explore
club cell	3 studies	23% ± 5%	Explore
amacrine cell	3 studies	41% ± 11%	Explore
dendritic cell	3 studies	47% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 10%	Explore
interneuron	3 studies	32% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	24% ± 8%	Explore
lung	6 studies	26% ± 3%	Explore
brain	6 studies	27% ± 10%	Explore
eye	5 studies	23% ± 7%	Explore
intestine	3 studies	25% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6101.91	1445 / 1445	100%	49.80	183 / 183
lung	100%	5851.16	578 / 578	100%	75.32	1155 / 1155
ovary	100%	5503.87	180 / 180	100%	57.39	430 / 430
pancreas	100%	4552.95	328 / 328	100%	67.19	178 / 178
prostate	100%	5648.22	245 / 245	100%	91.85	502 / 502
skin	100%	7019.70	1809 / 1809	100%	90.57	472 / 472
stomach	100%	5053.38	359 / 359	100%	66.58	286 / 286
uterus	100%	5393.17	170 / 170	100%	69.39	459 / 459
breast	100%	5579.25	459 / 459	100%	96.63	1117 / 1118
thymus	100%	5432.14	653 / 653	100%	75.13	604 / 605
intestine	100%	7716.40	966 / 966	100%	81.23	526 / 527
bladder	100%	6305.10	21 / 21	100%	76.46	503 / 504
kidney	100%	4662.31	89 / 89	100%	61.58	899 / 901
brain	100%	4762.27	2632 / 2642	100%	81.77	705 / 705
liver	100%	2522.75	226 / 226	99%	35.46	403 / 406
adrenal gland	100%	4536.74	258 / 258	98%	46.31	226 / 230
adipose	100%	5039.05	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	65.42	29 / 29
muscle	100%	5540.32	803 / 803	0%	0	0 / 0
peripheral blood	100%	13270.90	929 / 929	0%	0	0 / 0
spleen	100%	7291.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.04	45 / 45
ureter	0%	0	0 / 0	100%	46.54	1 / 1
blood vessel	100%	5733.51	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	98%	46.81	78 / 80
heart	96%	3863.33	823 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0005575	Cellular component	cellular_component
GO_0005829	Cellular component	cytosol
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	MKRN1
Protein name	E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) Makorin ring finger protein 1 MKRN1 protein
Synonyms	RNF61
Description	FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. .
Accessions	F8WEY8 ENST00000473444.1 C9JYX8 ENST00000498535.1 C9IY57 C9JYI0 ENST00000475180.5 ENST00000495305.5 ENST00000255977.7 [Q9UHC7-1] C9IZP5 H7C588 ENST00000474576.5 [Q9UHC7-2] ENST00000480552.5 Q9UHC7 A1L0W6 ENST00000443720.6 [Q9UHC7-4] ENST00000467513.5 ENST00000496169.5 F8WAS8 ENST00000463142.1 C9J031 ENST00000494939.1 H7C4H5 F8WBJ4 ENST00000471104.5

MKRN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review