METTL23 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	14 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	11 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	19% ± 3%	Explore
B cell	10 studies	19% ± 4%	Explore
regulatory T cell	10 studies	19% ± 2%	Explore
gamma-delta T cell	10 studies	21% ± 8%	Explore
CD4-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
memory B cell	8 studies	16% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 5%	Explore
mucosal invariant T cell	7 studies	19% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
naive B cell	6 studies	18% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	19% ± 2%	Explore
endothelial cell	5 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	5 studies	23% ± 4%	Explore
mature NK T cell	4 studies	19% ± 1%	Explore
plasma cell	4 studies	28% ± 10%	Explore
epithelial cell	4 studies	37% ± 14%	Explore
ciliated cell	4 studies	26% ± 4%	Explore
T cell	4 studies	18% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 3%	Explore
classical monocyte	3 studies	21% ± 5%	Explore
conventional dendritic cell	3 studies	27% ± 8%	Explore
hematopoietic precursor cell	3 studies	21% ± 7%	Explore
non-classical monocyte	3 studies	19% ± 4%	Explore
precursor B cell	3 studies	21% ± 2%	Explore
fibroblast	3 studies	20% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 5%	Explore
basal cell	3 studies	27% ± 9%	Explore
T follicular helper cell	3 studies	18% ± 1%	Explore
double negative thymocyte	3 studies	25% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	21% ± 5%	Explore
lung	4 studies	20% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	1089.38	21 / 21	100%	22.76	504 / 504
esophagus	100%	916.54	1445 / 1445	100%	21.92	183 / 183
liver	100%	887.06	226 / 226	100%	23.36	406 / 406
lung	100%	1153.64	578 / 578	100%	22.07	1155 / 1155
ovary	100%	1175.53	180 / 180	100%	25.07	430 / 430
pancreas	100%	967.59	328 / 328	100%	19.52	178 / 178
skin	100%	1168.20	1809 / 1809	100%	24.47	472 / 472
stomach	100%	952.69	359 / 359	100%	20.07	286 / 286
thymus	100%	1767.67	653 / 653	100%	28.29	605 / 605
intestine	100%	1088.41	966 / 966	100%	21.30	526 / 527
uterus	100%	1160.00	170 / 170	100%	22.78	458 / 459
kidney	100%	1287.62	89 / 89	100%	20.90	899 / 901
prostate	100%	1236.49	245 / 245	100%	21.43	500 / 502
breast	100%	1290.81	459 / 459	100%	23.82	1113 / 1118
brain	99%	632.38	2627 / 2642	100%	20.10	705 / 705
adrenal gland	100%	1301.02	258 / 258	99%	17.56	228 / 230
adipose	100%	1226.70	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	23.94	80 / 80
lymph node	0%	0	0 / 0	100%	32.42	29 / 29
spleen	100%	2025.32	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.34	45 / 45
ureter	0%	0	0 / 0	100%	22.40	1 / 1
blood vessel	100%	1184.19	1334 / 1335	0%	0	0 / 0
muscle	100%	814.65	800 / 803	0%	0	0 / 0
heart	98%	739.07	847 / 861	0%	0	0 / 0
peripheral blood	98%	903.16	910 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050890	Biological process	cognition
GO_0044725	Biological process	epigenetic programming in the zygotic pronuclei
GO_0032259	Biological process	methylation
GO_0018022	Biological process	peptidyl-lysine methylation
GO_0044727	Biological process	epigenetic programing of male pronucleus
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0001939	Cellular component	female pronucleus
GO_0001940	Cellular component	male pronucleus
GO_0032991	Cellular component	protein-containing complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0035642	Molecular function	histone H3R17 methyltransferase activity
GO_0031072	Molecular function	heat shock protein binding
GO_0035242	Molecular function	protein-arginine omega-N asymmetric methyltransferase activity
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0005515	Molecular function	protein binding
GO_0016279	Molecular function	protein-lysine N-methyltransferase activity

IV. Literature review

[source]

Gene name	METTL23
Protein name	Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23) Methyltransferase like 23
Synonyms	C17orf95
Description	FUNCTION: Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity). .
Accessions	K7EL83 ENST00000586738.5 ENST00000588783.5 ENST00000615984.4 [Q86XA0-1] ENST00000591571.5 K7ESG7 K7ERS2 ENST00000590964.5 [Q86XA0-2] ENST00000588964.1 ENST00000586752.5 [Q86XA0-2] K7EPR8 Q86XA0 K7EJ00 ENST00000588302.5 K7EPT5 ENST00000589977.5 ENST00000588822.1 [Q86XA0-2] ENST00000592849.5 ENST00000586200.1 K7ENU9 ENST00000341249.11 [Q86XA0-1] ENST00000588563.5 K7EMR3

METTL23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review