MAP4K1 | OmnibusX

Name	Number of supported studies	Average coverage
B cell	14 studies	22% ± 4%	Explore
memory B cell	12 studies	22% ± 4%	Explore
regulatory T cell	12 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	10 studies	21% ± 3%	Explore
plasmacytoid dendritic cell	10 studies	25% ± 6%	Explore
gamma-delta T cell	8 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	7 studies	18% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	20% ± 3%	Explore
mucosal invariant T cell	6 studies	19% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
dendritic cell	5 studies	33% ± 12%	Explore
exhausted T cell	4 studies	27% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
naive B cell	4 studies	18% ± 3%	Explore
T cell	4 studies	19% ± 3%	Explore
conventional dendritic cell	3 studies	35% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	16% ± 0%	Explore
germinal center B cell	3 studies	25% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 3%	Explore
natural killer cell	3 studies	20% ± 4%	Explore
double negative thymocyte	3 studies	19% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAP4K1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	726.30	577 / 578	92%	7.95	1058 / 1155
thymus	97%	403.53	633 / 653	78%	10.43	469 / 605
breast	91%	211.72	418 / 459	79%	5.63	879 / 1118
uterus	91%	152.76	155 / 170	78%	5.61	358 / 459
ovary	66%	88.77	118 / 180	97%	10.20	417 / 430
stomach	95%	258.98	341 / 359	65%	6.39	185 / 286
skin	72%	159.12	1304 / 1809	84%	10.73	398 / 472
kidney	79%	286.69	70 / 89	74%	4.74	667 / 901
intestine	92%	1012.57	888 / 966	59%	4.30	313 / 527
brain	87%	142.36	2290 / 2642	64%	2.75	448 / 705
esophagus	82%	170.58	1184 / 1445	66%	3.85	120 / 183
prostate	97%	306.31	237 / 245	47%	2.03	235 / 502
bladder	81%	283.81	17 / 21	57%	4.99	289 / 504
liver	91%	170.37	206 / 226	36%	2.15	147 / 406
adrenal gland	94%	157.05	242 / 258	15%	0.50	35 / 230
pancreas	30%	37.79	100 / 328	73%	6.29	130 / 178
lymph node	0%	0	0 / 0	100%	144.81	29 / 29
peripheral blood	100%	4612.43	929 / 929	0%	0	0 / 0
spleen	100%	6146.51	241 / 241	0%	0	0 / 0
adipose	97%	305.46	1167 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	12.55	40 / 45
blood vessel	64%	147.22	857 / 1335	0%	0	0 / 0
heart	50%	68.09	431 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	36%	2.24	29 / 80
muscle	26%	28.06	207 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007254	Biological process	JNK cascade
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_1904628	Biological process	cellular response to phorbol 13-acetate 12-myristate
GO_0006468	Biological process	protein phosphorylation
GO_0035556	Biological process	intracellular signal transduction
GO_0046777	Biological process	protein autophosphorylation
GO_0008283	Biological process	cell population proliferation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005515	Molecular function	protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0008349	Molecular function	MAP kinase kinase kinase kinase activity
GO_0005524	Molecular function	ATP binding

Gene name	MAP4K1
Protein name	non-specific serine/threonine protein kinase (EC 2.7.11.1) Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) Mitogen-activated protein kinase kinase kinase kinase 1 Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1)
Synonyms	HPK1
Description	FUNCTION: Serine/threonine-protein kinase, which may play a role in the response to environmental stress . Appears to act upstream of the JUN N-terminal pathway . May play a role in hematopoietic lineage decisions and growth regulation . Able to autophosphorylate . Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). . FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. .
Accessions	K7EKT6 K7EJS6 K7ERT2 ENST00000586296.5 K7ER95 ENST00000591517.5 [Q92918-1] ENST00000591921.1 ENST00000589130.5 ENST00000585583.5 ENST00000396857.7 [Q92918-2] Q92918

MAP4K1 report