LIME1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0051279Biological processregulation of release of sequestered calcium ion into cytosol
GO_0050853Biological processB cell receptor signaling pathway
GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1901222Biological processregulation of non-canonical NF-kappaB signal transduction
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0050852Biological processT cell receptor signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0019815Cellular componentB cell receptor complex
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIME1
Protein nameLck interacting transmembrane adaptor 1
Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule)
SynonymsLP8067
LIME
DescriptionFUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. .

AccessionsA0A087WT39
ENST00000309546.8 [Q9H400-1]
ENST00000476183.2
A0A087WZP9
V9GYI1
A0A087WUJ1
Q9H400
ENST00000487026.5
ENST00000493265.2
X6RKG5
ENST00000444951.5
ENST00000480139.5