LEPROT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	40% ± 15%	Explore
fibroblast	32 studies	41% ± 13%	Explore
pericyte	25 studies	40% ± 13%	Explore
macrophage	21 studies	23% ± 6%	Explore
smooth muscle cell	21 studies	33% ± 10%	Explore
classical monocyte	20 studies	25% ± 11%	Explore
endothelial cell of lymphatic vessel	18 studies	48% ± 13%	Explore
non-classical monocyte	16 studies	26% ± 13%	Explore
connective tissue cell	16 studies	34% ± 11%	Explore
myofibroblast cell	13 studies	36% ± 12%	Explore
capillary endothelial cell	12 studies	37% ± 7%	Explore
basal cell	11 studies	34% ± 17%	Explore
vein endothelial cell	11 studies	36% ± 7%	Explore
endothelial cell of vascular tree	11 studies	37% ± 11%	Explore
endothelial cell of artery	10 studies	44% ± 6%	Explore
epithelial cell	10 studies	38% ± 19%	Explore
platelet	9 studies	34% ± 10%	Explore
plasmacytoid dendritic cell	9 studies	20% ± 6%	Explore
monocyte	8 studies	23% ± 7%	Explore
type I pneumocyte	7 studies	38% ± 11%	Explore
conventional dendritic cell	7 studies	30% ± 12%	Explore
mesothelial cell	7 studies	29% ± 15%	Explore
hematopoietic stem cell	7 studies	34% ± 10%	Explore
ciliated cell	7 studies	37% ± 16%	Explore
alveolar macrophage	6 studies	33% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	28% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	23% ± 4%	Explore
secretory cell	5 studies	35% ± 19%	Explore
goblet cell	5 studies	23% ± 5%	Explore
mast cell	4 studies	18% ± 2%	Explore
glomerular endothelial cell	4 studies	52% ± 8%	Explore
megakaryocyte	4 studies	47% ± 13%	Explore
myeloid cell	4 studies	33% ± 15%	Explore
adventitial cell	4 studies	38% ± 10%	Explore
enteroendocrine cell	4 studies	29% ± 14%	Explore
hematopoietic precursor cell	3 studies	44% ± 29%	Explore
squamous epithelial cell	3 studies	40% ± 25%	Explore
pancreatic A cell	3 studies	37% ± 9%	Explore
pancreatic D cell	3 studies	46% ± 21%	Explore
type B pancreatic cell	3 studies	40% ± 9%	Explore
podocyte	3 studies	65% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	26% ± 9%	Explore
renal alpha-intercalated cell	3 studies	26% ± 3%	Explore
abnormal cell	3 studies	25% ± 7%	Explore
club cell	3 studies	31% ± 9%	Explore
astrocyte	3 studies	28% ± 9%	Explore
Mueller cell	3 studies	24% ± 8%	Explore
myoepithelial cell	3 studies	38% ± 11%	Explore
neuron	3 studies	28% ± 11%	Explore
dendritic cell	3 studies	38% ± 19%	Explore
pancreatic ductal cell	3 studies	55% ± 22%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	44% ± 24%	Explore
intestinal crypt stem cell	3 studies	18% ± 2%	Explore
glial cell	3 studies	28% ± 12%	Explore
mononuclear phagocyte	3 studies	30% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	32% ± 13%	Explore
intestine	7 studies	25% ± 12%	Explore
kidney	7 studies	21% ± 6%	Explore
peripheral blood	4 studies	27% ± 7%	Explore
uterus	4 studies	36% ± 13%	Explore
breast	4 studies	23% ± 3%	Explore
brain	4 studies	20% ± 3%	Explore
pancreas	3 studies	43% ± 11%	Explore
placenta	3 studies	40% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5954.70	1445 / 1445	100%	59.81	183 / 183
lung	100%	8735.50	578 / 578	100%	68.71	1155 / 1155
breast	100%	10126.16	459 / 459	100%	73.01	1116 / 1118
bladder	100%	7224.76	21 / 21	100%	54.46	503 / 504
prostate	100%	5379.29	245 / 245	100%	54.87	501 / 502
ovary	100%	8559.04	180 / 180	100%	54.70	429 / 430
kidney	100%	7722.72	89 / 89	99%	107.66	896 / 901
thymus	100%	8102.37	653 / 653	99%	82.97	601 / 605
stomach	100%	4952.50	359 / 359	99%	47.89	284 / 286
liver	100%	3270.09	226 / 226	99%	51.25	403 / 406
uterus	100%	8718.91	170 / 170	99%	51.22	455 / 459
intestine	100%	6103.14	966 / 966	99%	45.87	521 / 527
adrenal gland	100%	9251.89	258 / 258	99%	39.57	227 / 230
pancreas	99%	3532.59	325 / 328	99%	69.06	176 / 178
skin	100%	7204.78	1809 / 1809	97%	65.79	459 / 472
brain	94%	2765.82	2487 / 2642	100%	54.65	703 / 705
adipose	100%	10650.31	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9806.74	1335 / 1335	0%	0	0 / 0
spleen	100%	5535.81	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	33.42	1 / 1
heart	98%	4138.69	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	44.38	44 / 45
muscle	98%	2558.88	784 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	89%	31.27	71 / 80
lymph node	0%	0	0 / 0	86%	22.37	25 / 29
peripheral blood	77%	2244.48	718 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903955	Biological process	positive regulation of protein targeting to mitochondrion
GO_0060400	Biological process	negative regulation of growth hormone receptor signaling pathway
GO_0032511	Biological process	late endosome to vacuole transport via multivesicular body sorting pathway
GO_0046426	Biological process	negative regulation of receptor signaling pathway via JAK-STAT
GO_2000009	Biological process	negative regulation of protein localization to cell surface
GO_0010008	Cellular component	endosome membrane
GO_0000139	Cellular component	Golgi membrane
GO_0005768	Cellular component	endosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LEPROT
Protein name	Leptin receptor overlapping transcript Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP) Leptin receptor gene-related protein (Endospanin-1) (OB-R gene-related protein)
Synonyms	OBR LEPR
Description	FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. .
Accessions	ENST00000371065.9 A0A087X0N2 ENST00000475108.5 O15243 ENST00000488747.5 ENST00000613538.1 ENST00000484243.1 A0A3B3ITV1 A0A3B3ISI8 A0A3B3ISI6

LEPROT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review