ISCA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	16 studies	23% ± 8%	Explore
CD4-positive, alpha-beta T cell	11 studies	22% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 6%	Explore
CD8-positive, alpha-beta T cell	10 studies	22% ± 6%	Explore
regulatory T cell	10 studies	25% ± 9%	Explore
pericyte	10 studies	24% ± 8%	Explore
gamma-delta T cell	10 studies	25% ± 10%	Explore
smooth muscle cell	9 studies	26% ± 18%	Explore
fibroblast	9 studies	25% ± 11%	Explore
T cell	8 studies	18% ± 2%	Explore
endothelial cell	8 studies	25% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	27% ± 7%	Explore
platelet	7 studies	31% ± 10%	Explore
B cell	7 studies	22% ± 5%	Explore
mature NK T cell	7 studies	20% ± 6%	Explore
mucosal invariant T cell	7 studies	21% ± 6%	Explore
ciliated cell	7 studies	30% ± 13%	Explore
erythrocyte	6 studies	36% ± 14%	Explore
naive B cell	6 studies	20% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
epithelial cell	6 studies	34% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	30% ± 12%	Explore
memory B cell	5 studies	19% ± 2%	Explore
kidney loop of Henle epithelial cell	4 studies	21% ± 5%	Explore
retinal ganglion cell	4 studies	59% ± 28%	Explore
retina horizontal cell	4 studies	28% ± 11%	Explore
basal cell	4 studies	32% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	23% ± 7%	Explore
type B pancreatic cell	3 studies	29% ± 4%	Explore
conventional dendritic cell	3 studies	31% ± 8%	Explore
non-classical monocyte	3 studies	25% ± 5%	Explore
myofibroblast cell	3 studies	22% ± 1%	Explore
amacrine cell	3 studies	37% ± 10%	Explore
retinal rod cell	3 studies	19% ± 3%	Explore
CD4-positive helper T cell	3 studies	38% ± 11%	Explore
dendritic cell	3 studies	30% ± 7%	Explore
innate lymphoid cell	3 studies	31% ± 12%	Explore
macrophage	3 studies	24% ± 5%	Explore
abnormal cell	3 studies	22% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	31% ± 13%	Explore
GABAergic neuron	3 studies	35% ± 6%	Explore
glutamatergic neuron	3 studies	47% ± 9%	Explore
pancreatic A cell	3 studies	28% ± 5%	Explore
megakaryocyte	3 studies	37% ± 12%	Explore
intestinal crypt stem cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	24% ± 5%	Explore
lung	5 studies	21% ± 6%	Explore
eye	4 studies	23% ± 6%	Explore
brain	4 studies	31% ± 10%	Explore
pancreas	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2340.26	459 / 459	100%	40.38	1118 / 1118
liver	100%	1237.13	226 / 226	100%	26.42	406 / 406
ovary	100%	2013.44	180 / 180	100%	33.11	430 / 430
brain	100%	3096.72	2641 / 2642	100%	51.36	705 / 705
esophagus	100%	1758.88	1444 / 1445	100%	27.93	183 / 183
prostate	100%	1791.78	245 / 245	100%	38.58	501 / 502
kidney	100%	2686.69	89 / 89	100%	42.36	898 / 901
stomach	100%	1610.34	359 / 359	100%	25.97	285 / 286
uterus	100%	1954.32	170 / 170	100%	28.06	457 / 459
thymus	100%	2194.31	653 / 653	100%	31.74	602 / 605
pancreas	99%	968.36	326 / 328	100%	25.70	178 / 178
lung	99%	1517.99	573 / 578	100%	29.34	1154 / 1155
intestine	100%	2098.73	966 / 966	99%	25.79	521 / 527
bladder	100%	1909.76	21 / 21	99%	25.75	498 / 504
adrenal gland	100%	2841.96	258 / 258	99%	54.37	227 / 230
skin	100%	1594.68	1807 / 1809	98%	27.66	464 / 472
adipose	100%	2501.20	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.84	29 / 29
muscle	100%	3530.12	803 / 803	0%	0	0 / 0
spleen	100%	1507.62	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	25.30	45 / 45
ureter	0%	0	0 / 0	100%	14.53	1 / 1
blood vessel	100%	2224.12	1333 / 1335	0%	0	0 / 0
heart	99%	2506.98	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	26.89	77 / 80
peripheral blood	91%	966.18	849 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097428	Biological process	protein maturation by iron-sulfur cluster transfer
GO_0016226	Biological process	iron-sulfur cluster assembly
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0051537	Molecular function	2 iron, 2 sulfur cluster binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	ISCA1
Protein name	Iron-sulfur cluster assembly 1 Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA)
Synonyms	HBLD2 GK004
Description	FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. . FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. . FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. .
Accessions	Q5TBE2 ENST00000375991.9 [Q9BUE6-1] A0A1B0GTK6 Q9BUE6 ENST00000326094.4 Q5TBE9 ENST00000637705.1 ENST00000311534.6

ISCA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review