IRF9 report

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0006366Biological processtranscription by RNA polymerase II
GO_0002376Biological processimmune system process
GO_0007166Biological processcell surface receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070721Cellular componentISGF3 complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameIRF9
Protein nameInterferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
Interferon regulatory factor 9
SynonymsISGF3G
DescriptionFUNCTION: Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. .

AccessionsENST00000699067.1
ENST00000699104.1
ENST00000698995.1
A0A8V8TN47
H7BXP4
ENST00000396864.8
A0A8V8TMK5
A0A8V8TMU4
ENST00000560852.1
A0A8V8TP43
A0A8V8TMQ7
A0A8V8TMV6
ENST00000699180.1
ENST00000699100.1
A0A8V8TMP1
ENST00000699178.1
A0A8V8TMJ8
A0A8V8TP83
A0A8V8TP35
ENST00000699181.1
ENST00000699179.1
A0A8V8TPL3
H0YMB0
ENST00000699082.1
A0A8V8TPD7
ENST00000699079.1
H0YNP4
ENST00000699022.1
A0A8V8TMP6
ENST00000699099.1
ENST00000699015.1
A0A8V8TPF5
ENST00000699069.1
ENST00000699076.1
A0A8V8TP30
Q00978
A0A8V8TMP0
ENST00000699071.1
ENST00000560542.2
ENST00000699064.1
ENST00000698997.1
A0A8V8TPF1
ENST00000699083.1
ENST00000699105.1
ENST00000699081.1
ENST00000699077.1
ENST00000561342.6
ENST00000699108.1
ENST00000560275.6
ENST00000698998.1
ENST00000646071.2
ENST00000699184.1
ENST00000324076.5
ENST00000698996.1
ENST00000699107.1
ENST00000699101.1
A0A8V8TN13
A0A8V8TNB4
H0YNM9
ENST00000557894.6
ENST00000699063.1
A0A8V8TMN7