Name | Number of supported studies | Average coverage | |
---|---|---|---|
non-classical monocyte | 8 studies | 26% ± 11% | |
naive B cell | 6 studies | 18% ± 2% | |
B cell | 6 studies | 21% ± 6% | |
natural killer cell | 5 studies | 29% ± 8% | |
CD8-positive, alpha-beta T cell | 5 studies | 26% ± 7% | |
plasmacytoid dendritic cell | 5 studies | 20% ± 5% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 18% ± 1% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 24% ± 4% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 30% ± 6% | |
CD4-positive, alpha-beta T cell | 4 studies | 24% ± 5% | |
classical monocyte | 4 studies | 20% ± 6% | |
regulatory T cell | 4 studies | 22% ± 7% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 23% ± 6% | |
glomerular endothelial cell | 3 studies | 17% ± 1% | |
mucosal invariant T cell | 3 studies | 17% ± 2% | |
endothelial cell | 3 studies | 22% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 34% ± 15% | |
endothelial cell of vascular tree | 3 studies | 25% ± 6% | |
fibroblast | 3 studies | 20% ± 5% | |
pericyte | 3 studies | 24% ± 6% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 5 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3179.25 | 1445 / 1445 | 99% | 5.35 | 182 / 183 |
brain | 100% | 2533.30 | 2638 / 2642 | 96% | 4.69 | 678 / 705 |
ovary | 100% | 3431.13 | 180 / 180 | 96% | 5.58 | 412 / 430 |
uterus | 100% | 3639.84 | 170 / 170 | 92% | 4.89 | 424 / 459 |
stomach | 100% | 2875.64 | 359 / 359 | 92% | 3.14 | 263 / 286 |
lung | 100% | 4372.63 | 578 / 578 | 92% | 3.92 | 1057 / 1155 |
bladder | 100% | 3278.86 | 21 / 21 | 91% | 3.78 | 459 / 504 |
intestine | 100% | 3620.48 | 966 / 966 | 90% | 3.31 | 474 / 527 |
pancreas | 96% | 1466.76 | 314 / 328 | 93% | 4.02 | 166 / 178 |
breast | 100% | 3149.59 | 459 / 459 | 86% | 3.27 | 966 / 1118 |
thymus | 100% | 4042.62 | 653 / 653 | 84% | 2.52 | 508 / 605 |
prostate | 100% | 4022.25 | 245 / 245 | 78% | 2.50 | 394 / 502 |
skin | 100% | 2370.31 | 1808 / 1809 | 77% | 2.32 | 363 / 472 |
adrenal gland | 100% | 3818.17 | 258 / 258 | 73% | 1.66 | 167 / 230 |
kidney | 100% | 4498.20 | 89 / 89 | 68% | 2.59 | 617 / 901 |
liver | 100% | 2537.35 | 226 / 226 | 55% | 1.32 | 225 / 406 |
adipose | 100% | 3371.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 9603.79 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2933.76 | 1333 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 6356.61 | 925 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 1763.01 | 856 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 87% | 3.27 | 39 / 45 |
lymph node | 0% | 0 | 0 / 0 | 83% | 4.61 | 24 / 29 |
muscle | 65% | 597.59 | 524 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 38% | 1.10 | 30 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051607 | Biological process | defense response to virus |
GO_0006366 | Biological process | transcription by RNA polymerase II |
GO_0002376 | Biological process | immune system process |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0070721 | Cellular component | ISGF3 complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
Gene name | IRF9 |
Protein name | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) Interferon regulatory factor 9 |
Synonyms | ISGF3G |
Description | FUNCTION: Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. . |
Accessions | ENST00000699067.1 ENST00000699104.1 ENST00000698995.1 A0A8V8TN47 H7BXP4 ENST00000396864.8 A0A8V8TMK5 A0A8V8TMU4 ENST00000560852.1 A0A8V8TP43 A0A8V8TMQ7 A0A8V8TMV6 ENST00000699180.1 ENST00000699100.1 A0A8V8TMP1 ENST00000699178.1 A0A8V8TMJ8 A0A8V8TP83 A0A8V8TP35 ENST00000699181.1 ENST00000699179.1 A0A8V8TPL3 H0YMB0 ENST00000699082.1 A0A8V8TPD7 ENST00000699079.1 H0YNP4 ENST00000699022.1 A0A8V8TMP6 ENST00000699099.1 ENST00000699015.1 A0A8V8TPF5 ENST00000699069.1 ENST00000699076.1 A0A8V8TP30 Q00978 A0A8V8TMP0 ENST00000699071.1 ENST00000560542.2 ENST00000699064.1 ENST00000698997.1 A0A8V8TPF1 ENST00000699083.1 ENST00000699105.1 ENST00000699081.1 ENST00000699077.1 ENST00000561342.6 ENST00000699108.1 ENST00000560275.6 ENST00000698998.1 ENST00000646071.2 ENST00000699184.1 ENST00000324076.5 ENST00000698996.1 ENST00000699107.1 ENST00000699101.1 A0A8V8TN13 A0A8V8TNB4 H0YNM9 ENST00000557894.6 ENST00000699063.1 A0A8V8TMN7 |