IER5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	25 studies	37% ± 15%	Explore
non-classical monocyte	22 studies	40% ± 21%	Explore
conventional dendritic cell	22 studies	32% ± 12%	Explore
B cell	20 studies	32% ± 15%	Explore
monocyte	17 studies	34% ± 14%	Explore
endothelial cell	15 studies	32% ± 13%	Explore
classical monocyte	15 studies	32% ± 16%	Explore
dendritic cell	14 studies	46% ± 20%	Explore
fibroblast	13 studies	25% ± 10%	Explore
natural killer cell	12 studies	28% ± 10%	Explore
basal cell	10 studies	26% ± 6%	Explore
pericyte	9 studies	31% ± 10%	Explore
mast cell	8 studies	34% ± 9%	Explore
smooth muscle cell	8 studies	30% ± 9%	Explore
leukocyte	8 studies	33% ± 12%	Explore
epithelial cell	8 studies	29% ± 14%	Explore
naive B cell	7 studies	26% ± 6%	Explore
memory B cell	7 studies	30% ± 11%	Explore
T cell	6 studies	35% ± 19%	Explore
alveolar macrophage	6 studies	24% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	28% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	28% ± 14%	Explore
CD8-positive, alpha-beta T cell	6 studies	24% ± 7%	Explore
myeloid cell	6 studies	41% ± 13%	Explore
endothelial cell of vascular tree	6 studies	26% ± 11%	Explore
mononuclear phagocyte	5 studies	35% ± 14%	Explore
CD4-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
gamma-delta T cell	5 studies	32% ± 15%	Explore
endothelial cell of lymphatic vessel	4 studies	30% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	31% ± 15%	Explore
mature NK T cell	4 studies	26% ± 6%	Explore
mucosal invariant T cell	4 studies	26% ± 13%	Explore
neutrophil	4 studies	24% ± 8%	Explore
ciliated cell	4 studies	27% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	30% ± 13%	Explore
innate lymphoid cell	4 studies	32% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	41% ± 11%	Explore
regulatory T cell	4 studies	24% ± 5%	Explore
vein endothelial cell	4 studies	21% ± 5%	Explore
type II pneumocyte	3 studies	19% ± 4%	Explore
squamous epithelial cell	3 studies	43% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
glomerular endothelial cell	3 studies	30% ± 17%	Explore
secretory cell	3 studies	20% ± 3%	Explore
intermediate monocyte	3 studies	43% ± 20%	Explore
CD4-positive helper T cell	3 studies	32% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	18% ± 2%	Explore
capillary endothelial cell	3 studies	17% ± 2%	Explore
goblet cell	3 studies	21% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 12%	Explore
connective tissue cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	29% ± 9%	Explore
peripheral blood	5 studies	32% ± 10%	Explore
uterus	5 studies	22% ± 5%	Explore
intestine	4 studies	23% ± 4%	Explore
liver	4 studies	25% ± 9%	Explore
lymph node	3 studies	20% ± 1%	Explore
breast	3 studies	34% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	4479.87	1809 / 1809	100%	37.46	471 / 472
lung	100%	4624.29	577 / 578	100%	41.51	1154 / 1155
uterus	100%	2427.16	170 / 170	99%	78.45	456 / 459
bladder	100%	1694.05	21 / 21	99%	51.66	500 / 504
esophagus	99%	2640.01	1433 / 1445	99%	47.08	182 / 183
intestine	99%	2055.42	959 / 966	99%	29.05	522 / 527
breast	98%	1840.64	452 / 459	99%	35.21	1111 / 1118
thymus	92%	1072.36	600 / 653	99%	31.40	596 / 605
adrenal gland	95%	1184.80	244 / 258	88%	21.40	203 / 230
stomach	83%	1394.98	297 / 359	99%	24.84	282 / 286
brain	75%	1137.58	1970 / 2642	100%	34.40	703 / 705
prostate	92%	1167.56	226 / 245	65%	9.49	326 / 502
pancreas	52%	418.20	170 / 328	97%	39.39	173 / 178
kidney	57%	682.84	51 / 89	84%	17.91	758 / 901
liver	54%	575.46	123 / 226	83%	15.62	338 / 406
ovary	41%	454.90	73 / 180	93%	17.37	401 / 430
lymph node	0%	0	0 / 0	100%	78.99	29 / 29
spleen	100%	6603.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	63.96	45 / 45
ureter	0%	0	0 / 0	100%	20.34	1 / 1
muscle	99%	3848.28	795 / 803	0%	0	0 / 0
heart	98%	3229.29	848 / 861	0%	0	0 / 0
adipose	97%	1873.73	1169 / 1204	0%	0	0 / 0
blood vessel	95%	2111.86	1272 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	91%	25.23	73 / 80
peripheral blood	90%	3622.02	835 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1900036	Biological process	positive regulation of cellular response to heat
GO_0034605	Biological process	cellular response to heat
GO_0042127	Biological process	regulation of cell population proliferation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0000159	Cellular component	protein phosphatase type 2A complex
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IER5
Protein name	Immediate early response gene 5 protein Immediate early response 5
Synonyms	SBBI48 PP4583
Description	FUNCTION: Plays a role as a transcription factor . Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner . Mediates negative transcriptional regulation of CDC25B expression . Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A . Involved in the regulation of cell proliferation and resistance to thermal stress . Involved in the cell cycle checkpoint and survival in response to ionizing radiation . Associates with chromatin to the CDC25B promoter . .
Accessions	Q5VY09 ENST00000367577.7 Q32P56

IER5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review