HOOK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0097150Biological processneuronal stem cell population maintenance
GO_0031122Biological processcytoplasmic microtubule organization
GO_0051645Biological processGolgi localization
GO_1905719Biological processprotein localization to perinuclear region of cytoplasm
GO_0022027Biological processinterkinetic nuclear migration
GO_0071539Biological processprotein localization to centrosome
GO_0008333Biological processendosome to lysosome transport
GO_0007032Biological processendosome organization
GO_0015031Biological processprotein transport
GO_0034454Biological processmicrotubule anchoring at centrosome
GO_0045022Biological processearly endosome to late endosome transport
GO_0050768Biological processnegative regulation of neurogenesis
GO_0030705Biological processcytoskeleton-dependent intracellular transport
GO_0005801Cellular componentcis-Golgi network
GO_0030897Cellular componentHOPS complex
GO_0034451Cellular componentcentriolar satellite
GO_0005874Cellular componentmicrotubule
GO_0005813Cellular componentcentrosome
GO_0070695Cellular componentFHF complex
GO_0005737Cellular componentcytoplasm
GO_0000242Cellular componentpericentriolar material
GO_0034452Molecular functiondynactin binding
GO_0045503Molecular functiondynein light chain binding
GO_0042802Molecular functionidentical protein binding
GO_0008017Molecular functionmicrotubule binding
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHOOK3
Protein nameHook microtubule tethering protein 3
Protein Hook homolog 3 (h-hook3) (hHK3)
Synonyms
DescriptionFUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor . Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell . .; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. .

AccessionsENST00000526882.5
H0YE69
H0YDK4
ENST00000307602.9
H0YDM4
ENST00000533338.1
Q86VS8
ENST00000533539.2