Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 32 studies | 31% ± 15% | |
macrophage | 25 studies | 27% ± 13% | |
fibroblast | 25 studies | 24% ± 6% | |
pericyte | 25 studies | 27% ± 10% | |
classical monocyte | 18 studies | 25% ± 10% | |
smooth muscle cell | 16 studies | 22% ± 5% | |
oligodendrocyte | 14 studies | 39% ± 15% | |
astrocyte | 14 studies | 38% ± 16% | |
non-classical monocyte | 13 studies | 23% ± 10% | |
oligodendrocyte precursor cell | 13 studies | 38% ± 18% | |
dendritic cell | 12 studies | 30% ± 13% | |
endothelial cell of lymphatic vessel | 12 studies | 24% ± 6% | |
B cell | 11 studies | 20% ± 4% | |
glutamatergic neuron | 11 studies | 46% ± 26% | |
mast cell | 10 studies | 24% ± 7% | |
monocyte | 10 studies | 28% ± 8% | |
conventional dendritic cell | 10 studies | 26% ± 14% | |
microglial cell | 10 studies | 31% ± 12% | |
adipocyte | 10 studies | 30% ± 8% | |
type I pneumocyte | 9 studies | 28% ± 6% | |
GABAergic neuron | 9 studies | 48% ± 24% | |
plasmacytoid dendritic cell | 9 studies | 22% ± 7% | |
myofibroblast cell | 9 studies | 20% ± 5% | |
myeloid cell | 9 studies | 33% ± 8% | |
capillary endothelial cell | 8 studies | 18% ± 3% | |
natural killer cell | 7 studies | 18% ± 2% | |
type II pneumocyte | 7 studies | 23% ± 5% | |
neuron | 7 studies | 41% ± 20% | |
interneuron | 7 studies | 48% ± 23% | |
naive B cell | 6 studies | 19% ± 2% | |
CD16-negative, CD56-bright natural killer cell, human | 6 studies | 18% ± 2% | |
epithelial cell | 6 studies | 42% ± 18% | |
basal cell | 6 studies | 27% ± 9% | |
club cell | 6 studies | 26% ± 7% | |
endothelial cell of artery | 6 studies | 16% ± 1% | |
ciliated cell | 6 studies | 26% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 23% ± 8% | |
abnormal cell | 5 studies | 25% ± 10% | |
retinal ganglion cell | 5 studies | 26% ± 7% | |
retina horizontal cell | 5 studies | 21% ± 5% | |
vein endothelial cell | 5 studies | 23% ± 11% | |
lymphocyte | 5 studies | 24% ± 5% | |
endothelial cell of vascular tree | 5 studies | 26% ± 9% | |
connective tissue cell | 5 studies | 26% ± 6% | |
squamous epithelial cell | 4 studies | 32% ± 25% | |
granule cell | 4 studies | 25% ± 6% | |
memory B cell | 4 studies | 16% ± 1% | |
mononuclear phagocyte | 4 studies | 26% ± 10% | |
respiratory goblet cell | 4 studies | 26% ± 7% | |
goblet cell | 4 studies | 34% ± 24% | |
hematopoietic precursor cell | 3 studies | 23% ± 2% | |
glomerular endothelial cell | 3 studies | 20% ± 1% | |
GABAergic interneuron | 3 studies | 38% ± 3% | |
glial cell | 3 studies | 25% ± 6% | |
precursor B cell | 3 studies | 21% ± 3% | |
immature B cell | 3 studies | 19% ± 2% | |
amacrine cell | 3 studies | 18% ± 3% | |
retinal pigment epithelial cell | 3 studies | 30% ± 17% | |
GABAergic amacrine cell | 3 studies | 23% ± 5% | |
Mueller cell | 3 studies | 18% ± 3% | |
glycinergic amacrine cell | 3 studies | 19% ± 2% | |
retinal rod cell | 3 studies | 18% ± 1% | |
secretory cell | 3 studies | 26% ± 2% | |
regulatory T cell | 3 studies | 17% ± 0% | |
muscle cell | 3 studies | 30% ± 14% | |
neural progenitor cell | 3 studies | 29% ± 10% | |
ependymal cell | 3 studies | 34% ± 16% | |
adventitial cell | 3 studies | 22% ± 5% | |
alveolar macrophage | 3 studies | 33% ± 7% | |
T cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3490.64 | 1445 / 1445 | 100% | 26.56 | 183 / 183 |
brain | 100% | 2734.17 | 2635 / 2642 | 100% | 15.87 | 705 / 705 |
lung | 100% | 4120.75 | 578 / 578 | 100% | 15.85 | 1150 / 1155 |
ovary | 100% | 3059.34 | 180 / 180 | 99% | 9.46 | 426 / 430 |
thymus | 100% | 12791.71 | 653 / 653 | 99% | 22.07 | 597 / 605 |
prostate | 100% | 3802.59 | 245 / 245 | 99% | 11.00 | 495 / 502 |
breast | 100% | 3761.82 | 459 / 459 | 99% | 14.78 | 1102 / 1118 |
uterus | 100% | 4067.81 | 170 / 170 | 97% | 9.82 | 444 / 459 |
bladder | 100% | 3537.67 | 21 / 21 | 96% | 9.70 | 485 / 504 |
pancreas | 99% | 2109.64 | 325 / 328 | 97% | 11.36 | 172 / 178 |
kidney | 100% | 2327.49 | 89 / 89 | 94% | 11.24 | 848 / 901 |
adrenal gland | 100% | 2883.45 | 258 / 258 | 94% | 8.29 | 216 / 230 |
stomach | 100% | 2671.86 | 359 / 359 | 94% | 13.20 | 268 / 286 |
skin | 100% | 4079.92 | 1808 / 1809 | 92% | 12.10 | 433 / 472 |
intestine | 100% | 3631.19 | 966 / 966 | 89% | 8.48 | 471 / 527 |
liver | 100% | 1943.69 | 226 / 226 | 65% | 5.40 | 263 / 406 |
adipose | 100% | 3959.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4243.97 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3304.95 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2377.50 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.63 | 1 / 1 |
heart | 98% | 1719.71 | 842 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 9.43 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 93% | 7.74 | 27 / 29 |
peripheral blood | 86% | 1823.88 | 798 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 54% | 3.45 | 43 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007040 | Biological process | lysosome organization |
GO_0097150 | Biological process | neuronal stem cell population maintenance |
GO_0031122 | Biological process | cytoplasmic microtubule organization |
GO_0051645 | Biological process | Golgi localization |
GO_1905719 | Biological process | protein localization to perinuclear region of cytoplasm |
GO_0022027 | Biological process | interkinetic nuclear migration |
GO_0071539 | Biological process | protein localization to centrosome |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_0007032 | Biological process | endosome organization |
GO_0015031 | Biological process | protein transport |
GO_0034454 | Biological process | microtubule anchoring at centrosome |
GO_0045022 | Biological process | early endosome to late endosome transport |
GO_0050768 | Biological process | negative regulation of neurogenesis |
GO_0030705 | Biological process | cytoskeleton-dependent intracellular transport |
GO_0005801 | Cellular component | cis-Golgi network |
GO_0030897 | Cellular component | HOPS complex |
GO_0034451 | Cellular component | centriolar satellite |
GO_0005874 | Cellular component | microtubule |
GO_0005813 | Cellular component | centrosome |
GO_0070695 | Cellular component | FHF complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0000242 | Cellular component | pericentriolar material |
GO_0034452 | Molecular function | dynactin binding |
GO_0045503 | Molecular function | dynein light chain binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0051959 | Molecular function | dynein light intermediate chain binding |
GO_0045505 | Molecular function | dynein intermediate chain binding |
GO_0005515 | Molecular function | protein binding |
Gene name | HOOK3 |
Protein name | Hook microtubule tethering protein 3 Protein Hook homolog 3 (h-hook3) (hHK3) |
Synonyms | |
Description | FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor . Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell . .; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. . |
Accessions | ENST00000526882.5 H0YE69 H0YDK4 ENST00000307602.9 H0YDM4 ENST00000533338.1 Q86VS8 ENST00000533539.2 |