HBB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
erythrocyte	20 studies	83% ± 19%	Explore
natural killer cell	8 studies	35% ± 15%	Explore
erythroblast	8 studies	69% ± 30%	Explore
B cell	7 studies	37% ± 16%	Explore
endothelial cell	6 studies	28% ± 10%	Explore
pericyte	6 studies	26% ± 9%	Explore
T cell	6 studies	36% ± 13%	Explore
fibroblast	6 studies	23% ± 8%	Explore
classical monocyte	5 studies	33% ± 7%	Explore
non-classical monocyte	5 studies	37% ± 10%	Explore
smooth muscle cell	5 studies	25% ± 3%	Explore
naive B cell	5 studies	36% ± 17%	Explore
CD8-positive, alpha-beta T cell	4 studies	34% ± 17%	Explore
mature NK T cell	4 studies	37% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	41% ± 17%	Explore
mucosal invariant T cell	4 studies	37% ± 24%	Explore
gamma-delta T cell	4 studies	35% ± 10%	Explore
CD4-positive, alpha-beta T cell	3 studies	32% ± 20%	Explore
macrophage	3 studies	38% ± 17%	Explore
memory B cell	3 studies	46% ± 8%	Explore
plasma cell	3 studies	39% ± 27%	Explore
plasmacytoid dendritic cell	3 studies	43% ± 10%	Explore
regulatory T cell	3 studies	37% ± 18%	Explore
ciliated cell	3 studies	16% ± 1%	Explore
endothelial cell of vascular tree	3 studies	29% ± 9%	Explore
mast cell	3 studies	23% ± 6%	Explore
myeloid cell	3 studies	22% ± 5%	Explore
endothelial cell of lymphatic vessel	3 studies	26% ± 1%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	34% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	26% ± 8%	Explore
conventional dendritic cell	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
bone marrow	4 studies	38% ± 14%	Explore
liver	3 studies	41% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	87%	34436.03	77 / 89	79%	187.74	713 / 901
brain	60%	9532.38	1582 / 2642	94%	519.31	663 / 705
lung	85%	63880.19	492 / 578	62%	79.12	715 / 1155
thymus	57%	21266.84	373 / 653	73%	85.89	439 / 605
liver	69%	16847.89	157 / 226	40%	26.31	161 / 406
spleen	99%	144846.95	238 / 241	0%	0	0 / 0
adrenal gland	21%	3922.14	53 / 258	77%	194.39	177 / 230
peripheral blood	81%	5970824.82	757 / 929	0%	0	0 / 0
breast	45%	9708.06	208 / 459	30%	17.92	335 / 1118
ovary	20%	3931.01	36 / 180	55%	59.04	235 / 430
uterus	26%	5119.78	44 / 170	48%	127.35	221 / 459
bladder	24%	4654.33	5 / 21	49%	38.00	245 / 504
esophagus	29%	8605.80	418 / 1445	37%	30.61	67 / 183
intestine	19%	3552.13	182 / 966	46%	43.98	243 / 527
prostate	33%	5163.68	82 / 245	29%	11.46	147 / 502
heart	62%	19763.96	534 / 861	0%	0	0 / 0
stomach	14%	2677.03	51 / 359	47%	42.77	133 / 286
adipose	59%	16907.87	706 / 1204	0%	0	0 / 0
pancreas	7%	716.33	23 / 328	48%	73.13	86 / 178
blood vessel	42%	12874.50	555 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	38%	19.27	17 / 45
eye	0%	0	0 / 0	35%	40.79	28 / 80
skin	8%	909.55	141 / 1809	25%	27.46	117 / 472
lymph node	0%	0	0 / 0	28%	23.51	8 / 29
muscle	26%	3085.37	212 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042542	Biological process	response to hydrogen peroxide
GO_0098869	Biological process	cellular oxidant detoxification
GO_0015670	Biological process	carbon dioxide transport
GO_0070527	Biological process	platelet aggregation
GO_0008217	Biological process	regulation of blood pressure
GO_0042744	Biological process	hydrogen peroxide catabolic process
GO_0097746	Biological process	blood vessel diameter maintenance
GO_0070293	Biological process	renal absorption
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0015671	Biological process	oxygen transport
GO_0030185	Biological process	nitric oxide transport
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005833	Cellular component	hemoglobin complex
GO_0071682	Cellular component	endocytic vesicle lumen
GO_0070062	Cellular component	extracellular exosome
GO_0031838	Cellular component	haptoglobin-hemoglobin complex
GO_0072562	Cellular component	blood microparticle
GO_1904724	Cellular component	tertiary granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0004601	Molecular function	peroxidase activity
GO_0043177	Molecular function	organic acid binding
GO_0019825	Molecular function	oxygen binding
GO_0031721	Molecular function	hemoglobin alpha binding
GO_0020037	Molecular function	heme binding
GO_0046872	Molecular function	metal ion binding
GO_0005344	Molecular function	oxygen carrier activity
GO_0031720	Molecular function	haptoglobin binding
GO_0005515	Molecular function	protein binding
GO_0030492	Molecular function	hemoglobin binding

IV. Literature review

[source]

Gene name	HBB
Protein name	Beta-globin Truncated beta-globin Hemoglobin beta chain variant Hb.Sinai-Bel Air Beta-globin (Hemoglobin beta) (Hemoglobin subunit beta) Beta-globin (Globin A1) (Hemoglobin subunit beta) (Hemoglobin, beta) Hbbm fused globin protein Hemoglobin beta subunit variant Hemoglobin beta globin chain Beta-globin (Beta-hemoglobin) Beta globin (Hemoglobin) Beta-globin Tacoma variant Hemoglobin beta chain Beta globin Hemoglobin beta Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] Mutant beta globin Beta-globin Showa Yakushiji variant Hemoglobin subunit beta Beta globin chain Mutant hemoglobin beta chain Mutant beta-globin Beta globin (Hemoglobin beta chain) (Hemoglobin beta subunit) Hemoglobin beta chain variant Hb-I_Toulouse Beta-globin (Hemoglobin subunit beta)
Synonyms	GLNA1
Description	FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues. .; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Accessions	Q2XP30 B3VL86 Q3Y9I8 A0A0J9YWK4 ENST00000647020.1 Q14484 Q9UBV6 J7LKS8 A1YZ08 Q4JLR8 Q86VF0 Q9BWU5 ENST00000485743.1 O95412 Q4TZM4 Q14477 ENST00000633227.1 B5ANL9 ENST00000335295.4 D9YZU5 A9YUX2 Q6J1Z7 A0A481SHK9 Q9H1I5 C8C504 B2M1S6 Q52MT0 Q5GMQ1 Q6V0K9 Q9UK54 Q8IUL9 ENST00000380315.2 O95408 A0A2S1CVU8 Q0Z944 A0A3G5AXY7 Q8IZI0 A0A2R8Y7R2 E9NGZ5 Q9HAR8 Q9UP81 B2M1S7 Q3LR79 Q6VFQ6 Q9H1I6 Q9GZL9 E9M263 Q4TWB7 Q9Y6D8 P68871 Q6J1Z8 Q6VFQ5 Q9BWV6 F8W6P5 Q7Z2K5 B2M0Y1

HBB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review