GPHN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007529Biological processestablishment of synaptic specificity at neuromuscular junction
GO_0010038Biological processresponse to metal ion
GO_0006777Biological processMo-molybdopterin cofactor biosynthetic process
GO_0098970Biological processpostsynaptic neurotransmitter receptor diffusion trapping
GO_0032324Biological processmolybdopterin cofactor biosynthetic process
GO_0097112Biological processgamma-aminobutyric acid receptor clustering
GO_0072579Biological processglycine receptor clustering
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0097060Cellular componentsynaptic membrane
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0099572Cellular componentpostsynaptic specialization
GO_0099634Cellular componentpostsynaptic specialization membrane
GO_0061599Molecular functionmolybdopterin molybdotransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0008940Molecular functionnitrate reductase activity
GO_0043546Molecular functionmolybdopterin cofactor binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0061598Molecular functionmolybdopterin adenylyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPHN
Protein nameGephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]
molybdopterin molybdotransferase (EC 2.10.1.1)
Gephyrin [Includes: Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E); Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G)]
Gephyrin
SynonymsKIAA1385
GPH
DescriptionFUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors . .; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. .

FUNCTION: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. .

FUNCTION: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. .

AccessionsENST00000556240.1
G3V4R0
ENST00000555668.5
ENST00000555456.1
G3V582
G3V4D2
ENST00000555503.1
H0YIY4
ENST00000315266.9 [Q9NQX3-1]
ENST00000553936.5
H0YJ30
H0YJR5
ENST00000556633.5
Q9NQX3
ENST00000478722.6 [Q9NQX3-2]
ENST00000557654.5
ENST00000543237.5
G3V355
ENST00000459628.5
F5H039