GBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051715Biological processcytolysis in another organism
GO_0140639Biological processpositive regulation of pyroptotic inflammatory response
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0045087Biological processinnate immune response
GO_0042832Biological processdefense response to protozoan
GO_0072665Biological processprotein localization to vacuole
GO_0051607Biological processdefense response to virus
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0071347Biological processcellular response to interleukin-1
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0050848Biological processregulation of calcium-mediated signaling
GO_0042742Biological processdefense response to bacterium
GO_0160075Biological processnon-canonical inflammasome complex assembly
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0071346Biological processcellular response to type II interferon
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012506Cellular componentvesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0106139Cellular componentsymbiont cell surface
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0019003Molecular functionGDP binding
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0030507Molecular functionspectrin binding
GO_0051879Molecular functionHsp90 protein binding
GO_0019955Molecular functioncytokine binding
GO_0042802Molecular functionidentical protein binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0004382Molecular functionGDP phosphatase activity
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGBP1
Protein nameGuanylate binding protein 1
Guanylate-binding protein 1
Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1)
Synonyms
DescriptionFUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens . Hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner . Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both inflammasome assembly and autophagy . Acts as a positive regulator of inflammasome assembly by facilitating the detection of inflammasome ligands from pathogens . Involved in the lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, forms a protein coat in a GTPase-dependent manner that encapsulates pathogens and promotes the detection of ligands by pattern recognition receptors . Plays a key role in inflammasome assembly in response to infection by Gram-negative bacteria: following pathogen release in the cytosol, forms a protein coat that encapsulates Gram-negative bacteria and directly binds to lipopolysaccharide (LPS), disrupting the O-antigen barrier and unmasking lipid A that is that detected by the non-canonical inflammasome effector CASP4/CASP11 . Also promotes recruitment of proteins that mediate bacterial cytolysis, leading to release double-stranded DNA (dsDNA) that activates the AIM2 inflammasome . Involved in autophagy by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitinated proteins to autolysosomes for the generation of bacteriolytic peptides (By similarity). Confers protection to several pathogens, including the bacterial pathogens L.monocytogenes and M.bovis BCG as well as the protozoan pathogen T.gondii . Exhibits antiviral activity against influenza virus . .

AccessionsA0A348GSI6
P32455
ENST00000370473.5
A0A7P0TAZ1
ENST00000681280.1