FSCN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071803Biological processpositive regulation of podosome assembly
GO_0048870Biological processcell motility
GO_0007043Biological processcell-cell junction assembly
GO_0090091Biological processpositive regulation of extracellular matrix disassembly
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0032534Biological processregulation of microvillus assembly
GO_0051017Biological processactin filament bundle assembly
GO_0035089Biological processestablishment of apical/basal cell polarity
GO_0030036Biological processactin cytoskeleton organization
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0030035Biological processmicrospike assembly
GO_0030046Biological processparallel actin filament bundle assembly
GO_0016477Biological processcell migration
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0001726Cellular componentruffle
GO_0005902Cellular componentmicrovillus
GO_0005856Cellular componentcytoskeleton
GO_0070062Cellular componentextracellular exosome
GO_0002102Cellular componentpodosome
GO_0005911Cellular componentcell-cell junction
GO_0044393Cellular componentmicrospike
GO_0030175Cellular componentfilopodium
GO_0001725Cellular componentstress fiber
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0030426Cellular componentgrowth cone
GO_0031253Cellular componentcell projection membrane
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0045296Molecular functioncadherin binding
GO_0051015Molecular functionactin filament binding
GO_0003779Molecular functionactin binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFSCN1
Protein nameFascin actin-bundling protein 1
Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
SynonymsFAN1
HSN
SNL
DescriptionFUNCTION: Actin-binding protein that contains 2 major actin binding sites . Organizes filamentous actin into parallel bundles . Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers . Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration . Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF . .

AccessionsC9JFC0
ENST00000382361.8
Q16658
ENST00000447103.5
ENST00000405801.2
C9JPH9
A0A0A0MSB2
ENST00000444748.5