FNTA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090045Biological processpositive regulation of deacetylase activity
GO_0071340Biological processskeletal muscle acetylcholine-gated channel clustering
GO_0018343Biological processprotein farnesylation
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0018344Biological processprotein geranylgeranylation
GO_0090044Biological processpositive regulation of tubulin deacetylation
GO_1904395Biological processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0005965Cellular componentprotein farnesyltransferase complex
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005953Cellular componentCAAX-protein geranylgeranyltransferase complex
GO_0005875Cellular componentmicrotubule associated complex
GO_0004662Molecular functionCAAX-protein geranylgeranyltransferase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0043014Molecular functionalpha-tubulin binding
GO_0004660Molecular functionprotein farnesyltransferase activity
GO_0008017Molecular functionmicrotubule binding
GO_0004661Molecular functionprotein geranylgeranyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0004663Molecular functionRab geranylgeranyltransferase activity

IV. Literature review

[source]
Gene nameFNTA
Protein nameFarnesyltransferase, CAAX box, alpha
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha)
SynonymshCG_1993221
DescriptionFUNCTION: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. .

AccessionsE9PK84
ENST00000525699.5
E9PN85
ENST00000529687.5
H0YCW1
ENST00000533336.1
ENST00000533998.5
E9PPM9
ENST00000533383.5
E9PQP6
ENST00000302279.8 [P49354-1]
ENST00000526755.5
P49354
ENST00000531266.5
B3KVN2