FDX1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	14 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	14 studies	22% ± 7%	Explore
natural killer cell	12 studies	20% ± 5%	Explore
CD4-positive, alpha-beta T cell	12 studies	21% ± 5%	Explore
macrophage	10 studies	25% ± 9%	Explore
endothelial cell	10 studies	23% ± 9%	Explore
plasma cell	9 studies	29% ± 12%	Explore
gamma-delta T cell	9 studies	24% ± 11%	Explore
plasmablast	7 studies	43% ± 21%	Explore
pericyte	7 studies	22% ± 4%	Explore
fibroblast	7 studies	25% ± 7%	Explore
epithelial cell	7 studies	41% ± 17%	Explore
classical monocyte	6 studies	25% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
non-classical monocyte	6 studies	31% ± 13%	Explore
mature NK T cell	6 studies	17% ± 1%	Explore
enterocyte	6 studies	21% ± 2%	Explore
mucosal invariant T cell	6 studies	19% ± 2%	Explore
myeloid cell	6 studies	27% ± 8%	Explore
basal cell	6 studies	33% ± 13%	Explore
regulatory T cell	6 studies	21% ± 6%	Explore
B cell	5 studies	21% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	17% ± 1%	Explore
conventional dendritic cell	5 studies	30% ± 14%	Explore
ciliated cell	5 studies	33% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	21% ± 8%	Explore
hematopoietic precursor cell	4 studies	25% ± 7%	Explore
secretory cell	4 studies	26% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 7%	Explore
epithelial cell of proximal tubule	4 studies	33% ± 7%	Explore
intestinal crypt stem cell	4 studies	23% ± 4%	Explore
retina horizontal cell	4 studies	19% ± 6%	Explore
alveolar macrophage	4 studies	27% ± 6%	Explore
innate lymphoid cell	4 studies	16% ± 1%	Explore
dendritic cell	4 studies	39% ± 16%	Explore
plasmacytoid dendritic cell	4 studies	25% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	21% ± 4%	Explore
T cell	4 studies	22% ± 9%	Explore
pancreatic A cell	3 studies	21% ± 2%	Explore
leukocyte	3 studies	24% ± 4%	Explore
exhausted T cell	3 studies	22% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	25% ± 7%	Explore
progenitor cell	3 studies	19% ± 3%	Explore
smooth muscle cell	3 studies	24% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	44% ± 3%	Explore
extravillous trophoblast	3 studies	41% ± 16%	Explore
placental villous trophoblast	3 studies	61% ± 19%	Explore
lymphocyte	3 studies	20% ± 5%	Explore
monocyte	3 studies	21% ± 3%	Explore
endothelial cell of lymphatic vessel	3 studies	26% ± 3%	Explore
GABAergic neuron	3 studies	35% ± 7%	Explore
glutamatergic neuron	3 studies	41% ± 9%	Explore
T-helper 17 cell	3 studies	21% ± 5%	Explore
astrocyte	3 studies	20% ± 2%	Explore
hepatocyte	3 studies	49% ± 20%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	23% ± 7%	Explore
lung	6 studies	29% ± 9%	Explore
kidney	5 studies	20% ± 5%	Explore
brain	5 studies	26% ± 7%	Explore
placenta	4 studies	35% ± 13%	Explore
intestine	4 studies	22% ± 9%	Explore
pancreas	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1006.07	1445 / 1445	100%	26.65	183 / 183
liver	100%	2565.31	226 / 226	100%	39.12	406 / 406
ovary	100%	819.67	180 / 180	100%	20.70	430 / 430
pancreas	100%	966.77	328 / 328	100%	26.51	178 / 178
stomach	100%	1227.09	359 / 359	100%	28.38	286 / 286
thymus	100%	1760.60	653 / 653	100%	37.15	605 / 605
intestine	100%	1170.21	966 / 966	100%	28.98	526 / 527
bladder	100%	913.24	21 / 21	100%	29.75	503 / 504
prostate	100%	1045.96	245 / 245	100%	27.52	501 / 502
uterus	100%	736.58	170 / 170	100%	22.72	458 / 459
lung	100%	1357.96	577 / 578	100%	28.92	1154 / 1155
kidney	100%	2281.44	89 / 89	100%	25.57	898 / 901
adrenal gland	100%	42354.45	258 / 258	100%	210.73	229 / 230
breast	100%	1053.10	459 / 459	100%	19.20	1113 / 1118
brain	99%	765.10	2628 / 2642	100%	23.10	705 / 705
skin	100%	1001.31	1804 / 1809	97%	17.94	457 / 472
adipose	100%	1128.53	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.73	29 / 29
muscle	100%	1448.97	803 / 803	0%	0	0 / 0
spleen	100%	882.48	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.36	45 / 45
ureter	0%	0	0 / 0	100%	41.27	1 / 1
blood vessel	100%	806.50	1330 / 1335	0%	0	0 / 0
heart	98%	1292.50	842 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	12.51	75 / 80
peripheral blood	64%	415.80	592 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008203	Biological process	cholesterol metabolic process
GO_0042446	Biological process	hormone biosynthetic process
GO_0022900	Biological process	electron transport chain
GO_0071320	Biological process	cellular response to cAMP
GO_0140647	Biological process	P450-containing electron transport chain
GO_1904322	Biological process	cellular response to forskolin
GO_0006694	Biological process	steroid biosynthetic process
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0051537	Molecular function	2 iron, 2 sulfur cluster binding
GO_0005506	Molecular function	iron ion binding
GO_0009055	Molecular function	electron transfer activity

IV. Literature review

[source]

Gene name	FDX1
Protein name	Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)
Synonyms	ADX
Description	FUNCTION: Essential for the synthesis of various steroid hormones . Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis . Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage . Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). .
Accessions	P10109 ENST00000260270.3

FDX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review