Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 31 studies | 49% ± 20% | |
B cell | 28 studies | 34% ± 21% | |
macrophage | 22 studies | 46% ± 26% | |
plasmacytoid dendritic cell | 19 studies | 52% ± 15% | |
astrocyte | 18 studies | 40% ± 16% | |
oligodendrocyte precursor cell | 16 studies | 65% ± 21% | |
microglial cell | 16 studies | 70% ± 16% | |
naive B cell | 16 studies | 27% ± 7% | |
oligodendrocyte | 15 studies | 50% ± 18% | |
memory B cell | 14 studies | 22% ± 4% | |
smooth muscle cell | 13 studies | 41% ± 15% | |
fibroblast | 12 studies | 40% ± 12% | |
GABAergic neuron | 11 studies | 60% ± 21% | |
glutamatergic neuron | 11 studies | 46% ± 22% | |
pericyte | 11 studies | 36% ± 15% | |
endothelial cell of lymphatic vessel | 10 studies | 44% ± 19% | |
dendritic cell | 10 studies | 48% ± 20% | |
mast cell | 9 studies | 29% ± 15% | |
myeloid cell | 9 studies | 46% ± 22% | |
plasma cell | 7 studies | 41% ± 24% | |
interneuron | 6 studies | 70% ± 16% | |
adipocyte | 6 studies | 32% ± 10% | |
capillary endothelial cell | 6 studies | 36% ± 18% | |
vein endothelial cell | 6 studies | 44% ± 20% | |
neuron | 5 studies | 53% ± 19% | |
epithelial cell | 5 studies | 30% ± 8% | |
cardiac muscle cell | 5 studies | 57% ± 14% | |
endothelial cell of artery | 5 studies | 42% ± 19% | |
mesothelial cell | 5 studies | 37% ± 15% | |
T cell | 5 studies | 31% ± 8% | |
monocyte | 5 studies | 45% ± 11% | |
type I pneumocyte | 5 studies | 28% ± 6% | |
type II pneumocyte | 5 studies | 45% ± 11% | |
granule cell | 4 studies | 36% ± 6% | |
precursor B cell | 4 studies | 21% ± 2% | |
immature B cell | 4 studies | 27% ± 2% | |
Mueller cell | 4 studies | 38% ± 9% | |
amacrine cell | 4 studies | 45% ± 7% | |
retina horizontal cell | 4 studies | 36% ± 11% | |
retinal cone cell | 4 studies | 45% ± 10% | |
retinal rod cell | 4 studies | 41% ± 7% | |
club cell | 4 studies | 29% ± 8% | |
natural killer cell | 4 studies | 26% ± 3% | |
leukocyte | 4 studies | 60% ± 14% | |
abnormal cell | 4 studies | 29% ± 20% | |
endothelial cell of sinusoid | 3 studies | 47% ± 8% | |
classical monocyte | 3 studies | 18% ± 0% | |
plasmablast | 3 studies | 27% ± 11% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 54% ± 9% | |
GABAergic interneuron | 3 studies | 62% ± 3% | |
CD4-positive, alpha-beta T cell | 3 studies | 23% ± 2% | |
CD8-positive, alpha-beta T cell | 3 studies | 23% ± 6% | |
mononuclear phagocyte | 3 studies | 45% ± 21% | |
GABAergic amacrine cell | 3 studies | 65% ± 8% | |
glycinergic amacrine cell | 3 studies | 42% ± 8% | |
retinal ganglion cell | 3 studies | 53% ± 8% | |
endothelial cell of vascular tree | 3 studies | 62% ± 13% | |
hepatocyte | 3 studies | 58% ± 20% | |
retinal pigment epithelial cell | 3 studies | 45% ± 18% | |
connective tissue cell | 3 studies | 31% ± 12% | |
ependymal cell | 3 studies | 37% ± 13% | |
alveolar macrophage | 3 studies | 47% ± 6% | |
ciliated cell | 3 studies | 25% ± 8% | |
respiratory goblet cell | 3 studies | 35% ± 16% | |
lymphocyte | 3 studies | 41% ± 8% | |
muscle cell | 3 studies | 38% ± 24% | |
basal cell | 3 studies | 37% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2900.09 | 2640 / 2642 | 100% | 80.32 | 705 / 705 |
uterus | 100% | 2626.28 | 170 / 170 | 100% | 21.52 | 458 / 459 |
ovary | 100% | 3539.08 | 180 / 180 | 100% | 25.80 | 429 / 430 |
thymus | 100% | 2171.86 | 652 / 653 | 100% | 27.01 | 604 / 605 |
breast | 100% | 2992.12 | 459 / 459 | 100% | 25.53 | 1113 / 1118 |
lung | 100% | 4162.43 | 578 / 578 | 99% | 23.59 | 1149 / 1155 |
bladder | 100% | 2486.38 | 21 / 21 | 99% | 19.19 | 497 / 504 |
esophagus | 99% | 1888.38 | 1428 / 1445 | 99% | 20.46 | 182 / 183 |
adrenal gland | 100% | 2674.49 | 258 / 258 | 98% | 17.29 | 226 / 230 |
intestine | 100% | 2397.47 | 965 / 966 | 97% | 15.47 | 511 / 527 |
stomach | 100% | 1620.93 | 359 / 359 | 96% | 16.74 | 275 / 286 |
kidney | 98% | 1827.35 | 87 / 89 | 97% | 23.10 | 877 / 901 |
prostate | 99% | 1985.86 | 243 / 245 | 91% | 11.37 | 459 / 502 |
skin | 99% | 1616.07 | 1791 / 1809 | 91% | 14.94 | 428 / 472 |
pancreas | 87% | 767.79 | 286 / 328 | 98% | 22.55 | 174 / 178 |
liver | 96% | 1133.49 | 218 / 226 | 85% | 10.14 | 347 / 406 |
adipose | 100% | 3675.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6490.87 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 48.25 | 29 / 29 |
spleen | 100% | 5107.32 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 20.12 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.45 | 1 / 1 |
heart | 99% | 1955.41 | 854 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 3045.85 | 882 / 929 | 0% | 0 | 0 / 0 |
muscle | 81% | 747.86 | 654 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 74% | 7.86 | 59 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000601 | Biological process | positive regulation of Arp2/3 complex-mediated actin nucleation |
GO_0015031 | Biological process | protein transport |
GO_0030838 | Biological process | positive regulation of actin filament polymerization |
GO_0072583 | Biological process | clathrin-dependent endocytosis |
GO_0061024 | Biological process | membrane organization |
GO_0030833 | Biological process | regulation of actin filament polymerization |
GO_0007274 | Biological process | neuromuscular synaptic transmission |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0120043 | Cellular component | stereocilium shaft |
GO_0070161 | Cellular component | anchoring junction |
GO_0005886 | Cellular component | plasma membrane |
GO_0031594 | Cellular component | neuromuscular junction |
GO_0055037 | Cellular component | recycling endosome |
GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
GO_0005515 | Molecular function | protein binding |
GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
Gene name | FCHSD2 |
Protein name | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) FCH and double SH3 domains 2 |
Synonyms | KIAA0769 SH3MD3 |
Description | FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor . Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling . Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits . Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate . When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes . . |
Accessions | ENST00000432043.2 ENST00000409263.5 ENST00000409314.5 ENST00000409853.5 [O94868-3] ENST00000311172.11 [O94868-2] ENST00000409418.9 [O94868-1] H0YG35 H0Y6M2 ENST00000543644.1 C9JM66 ENST00000458644.6 E7ENZ2 E9PG19 ENST00000422375.1 B8ZZW8 O94868 |