ERN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0071333Biological processcellular response to glucose stimulus
GO_0034620Biological processcellular response to unfolded protein
GO_0006402Biological processmRNA catabolic process
GO_0033120Biological processpositive regulation of RNA splicing
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_1990579Biological processpeptidyl-serine trans-autophosphorylation
GO_1900103Biological processpositive regulation of endoplasmic reticulum unfolded protein response
GO_0036498Biological processIRE1-mediated unfolded protein response
GO_0001935Biological processendothelial cell proliferation
GO_1901142Biological processinsulin metabolic process
GO_0070054Biological processmRNA splicing, via endonucleolytic cleavage and ligation
GO_0016241Biological processregulation of macroautophagy
GO_0006468Biological processprotein phosphorylation
GO_0036289Biological processpeptidyl-serine autophosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0070301Biological processcellular response to hydrogen peroxide
GO_1990332Cellular componentIre1 complex
GO_1990604Cellular componentIRE1-TRAF2-ASK1 complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_1990597Cellular componentAIP1-IRE1 complex
GO_0005637Cellular componentnuclear inner membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_1990630Cellular componentIRE1-RACK1-PP2A complex
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004521Molecular functionRNA endonuclease activity
GO_0043531Molecular functionADP binding
GO_0005161Molecular functionplatelet-derived growth factor receptor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0051879Molecular functionHsp90 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0051082Molecular functionunfolded protein binding
GO_0030544Molecular functionHsp70 protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERN1
Protein nameSerine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Endoplasmic reticulum to nucleus signaling 1
SynonymsIRE1
DescriptionFUNCTION: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) . In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP . Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity . The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA . The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes . Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A . .

AccessionsA0A7P0TAB0
A0A7P0TA38
ENST00000680493.1
ENST00000680433.1
ENST00000433197.4 [O75460-1]
O75460
ENST00000606895.2 [O75460-2]