I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal rod cell | 7 studies | 29% ± 7% | |
| retinal bipolar neuron | 4 studies | 26% ± 6% | |
| retinal cone cell | 4 studies | 31% ± 14% | |
| rod bipolar cell | 3 studies | 45% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal rod cell | 7 studies | 29% ± 7% | |
| retinal bipolar neuron | 4 studies | 26% ± 6% | |
| retinal cone cell | 4 studies | 31% ± 14% | |
| rod bipolar cell | 3 studies | 45% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| eye | 5 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 99% | 244.03 | 179 / 180 | 97% | 12.40 | 419 / 430 |
| esophagus | 93% | 113.64 | 1351 / 1445 | 97% | 4.76 | 178 / 183 |
| brain | 99% | 147.84 | 2608 / 2642 | 92% | 4.09 | 646 / 705 |
| pancreas | 90% | 63.75 | 296 / 328 | 81% | 3.35 | 145 / 178 |
| uterus | 99% | 197.82 | 169 / 170 | 69% | 2.05 | 317 / 459 |
| intestine | 96% | 102.80 | 932 / 966 | 72% | 2.05 | 377 / 527 |
| bladder | 100% | 131.57 | 21 / 21 | 66% | 2.00 | 335 / 504 |
| kidney | 98% | 84.19 | 87 / 89 | 67% | 2.10 | 603 / 901 |
| stomach | 84% | 52.82 | 303 / 359 | 78% | 2.56 | 224 / 286 |
| thymus | 98% | 137.96 | 642 / 653 | 64% | 1.73 | 389 / 605 |
| lung | 90% | 93.32 | 519 / 578 | 68% | 2.23 | 782 / 1155 |
| breast | 92% | 64.66 | 420 / 459 | 63% | 1.84 | 702 / 1118 |
| adrenal gland | 84% | 52.43 | 218 / 258 | 65% | 2.39 | 150 / 230 |
| prostate | 99% | 174.20 | 242 / 245 | 45% | 0.83 | 225 / 502 |
| liver | 75% | 51.37 | 170 / 226 | 55% | 2.63 | 222 / 406 |
| skin | 79% | 75.34 | 1426 / 1809 | 30% | 0.66 | 143 / 472 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.80 | 1 / 1 |
| blood vessel | 94% | 81.65 | 1254 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 91% | 71.68 | 1097 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 86% | 3.06 | 69 / 80 |
| spleen | 80% | 43.57 | 193 / 241 | 0% | 0 | 0 / 0 |
| muscle | 68% | 42.78 | 550 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 1.83 | 30 / 45 |
| heart | 57% | 32.64 | 489 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 0.93 | 12 / 29 |
| peripheral blood | 22% | 7.28 | 205 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034776 | Biological process | response to histamine |
| GO_0051586 | Biological process | positive regulation of dopamine uptake involved in synaptic transmission |
| GO_0007195 | Biological process | adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| GO_0048149 | Biological process | behavioral response to ethanol |
| GO_0042053 | Biological process | regulation of dopamine metabolic process |
| GO_0008344 | Biological process | adult locomotory behavior |
| GO_1901386 | Biological process | negative regulation of voltage-gated calcium channel activity |
| GO_0042417 | Biological process | dopamine metabolic process |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0050709 | Biological process | negative regulation of protein secretion |
| GO_0042752 | Biological process | regulation of circadian rhythm |
| GO_0032417 | Biological process | positive regulation of sodium:proton antiporter activity |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0042596 | Biological process | fear response |
| GO_0033674 | Biological process | positive regulation of kinase activity |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0001662 | Biological process | behavioral fear response |
| GO_0001963 | Biological process | synaptic transmission, dopaminergic |
| GO_0001975 | Biological process | response to amphetamine |
| GO_0007198 | Biological process | adenylate cyclase-inhibiting serotonin receptor signaling pathway |
| GO_0048148 | Biological process | behavioral response to cocaine |
| GO_0035176 | Biological process | social behavior |
| GO_0007212 | Biological process | G protein-coupled dopamine receptor signaling pathway |
| GO_0048511 | Biological process | rhythmic process |
| GO_0060080 | Biological process | inhibitory postsynaptic potential |
| GO_0050482 | Biological process | arachidonic acid secretion |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0098794 | Cellular component | postsynapse |
| GO_0030425 | Cellular component | dendrite |
| GO_0004952 | Molecular function | dopamine neurotransmitter receptor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0051380 | Molecular function | norepinephrine binding |
| GO_0001591 | Molecular function | dopamine neurotransmitter receptor activity, coupled via Gi/Go |
| GO_0051379 | Molecular function | epinephrine binding |
| GO_0030594 | Molecular function | neurotransmitter receptor activity |
| GO_0015459 | Molecular function | potassium channel regulator activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0035240 | Molecular function | dopamine binding |
| GO_0051378 | Molecular function | serotonin binding |
| GO_0004993 | Molecular function | G protein-coupled serotonin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0017124 | Molecular function | SH3 domain binding |
| Gene name | DRD4 |
| Protein name | D(4) dopamine receptor D(4) dopamine receptor (Dopamine receptor D4) Dopamine D4 receptor (Dopamine receptor D4) Dopamine D4 receptor Dopamine receptor D4 D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) |
| Synonyms | receptor/ dopamine D4 |
| Description | FUNCTION: Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs . Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase . Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). . |
| Accessions | Q16303 Q8IZB6 K9MAU8 Q8WTT6 Q8WTR5 Q8WTR3 Q8WTS7 K9MAQ4 Q8IZB5 Q8WXL8 Q8WXM9 Q8WXN9 Q8WXP3 K9MAZ1 Q8WXN3 Q8IZB9 P21917 F6K0T3 Q8WXP0 F6K0T8 Q8WXN2 Q8WXL5 Q8WXM0 Q8WTS5 Q8WXM6 Q8WXL7 Q8WXP7 G5CTX6 ENST00000176183.6 K9MAQ3 Q8WXM5 Q8IZC0 A4LB54 Q8IZB2 Q8WXN1 K9MAU6 Q8WXN6 F6K0T7 Q76E76 K9MB71 K9MAZ0 Q8WXP6 Q8WXN7 Q8WTQ0 A4LB56 Q8WXM1 G9HV62 Q8IZB1 K9MAQ5 Q8WXN0 Q8WXP5 F6K0T9 G9HV63 K9MB45 Q8WXM4 Q8IZB8 Q8WXP2 G9HV65 Q8WTR9 Q8WTT7 Q8WXM3 F6K0U0 Q8WTQ5 Q8WXL6 Q8IZB3 Q8WXM7 Q8IZB4 Q8WXN4 Q8IZB7 K9MB44 Q8WXP4 K9MB72 G9HV64 Q8WXL9 A4LBB9 Q8WXM8 Q8WXN8 Q0MTB9 Q0MTB8 Q8WXP1 ENST00000611962.2 Q8WTT3 A4LB49 Q8WXN5 |
