DNAJC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006260Biological processDNA replication
GO_1900034Biological processregulation of cellular response to heat
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006450Biological processregulation of translational fidelity
GO_0051083Biological process'de novo' cotranslational protein folding
GO_2000279Biological processnegative regulation of DNA biosynthetic process
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0043022Molecular functionribosome binding
GO_0030544Molecular functionHsp70 protein binding
GO_0003723Molecular functionRNA binding
GO_0061649Molecular functionubiquitin-modified histone reader activity
GO_0005515Molecular functionprotein binding
GO_0001671Molecular functionATPase activator activity

IV. Literature review

[source]
Gene nameDNAJC2
Protein nameDNAJC2 protein
DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]
DnaJ heat shock protein family (Hsp40) member C2
SynonymsMPP11
ZRF1
MPHOSPH11
DescriptionFUNCTION: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. .

AccessionsENST00000379263.8 [Q99543-1]
H7C3L7
ENST00000412522.1
F2Z3N9
C9IZ83
ENST00000426036.6
ENST00000379257.7
ENST00000454277.5
ENST00000249270.11 [Q99543-2]
F2Z3H0
Q08AR5
Q6P5S9
Q99543