DGKZ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0046339Biological processdiacylglycerol metabolic process
GO_0046486Biological processglycerolipid metabolic process
GO_0046834Biological processlipid phosphorylation
GO_0030168Biological processplatelet activation
GO_0035556Biological processintracellular signal transduction
GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0016477Biological processcell migration
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0047649Molecular functionalkylglycerol kinase activity
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDGKZ
Protein nameDiacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta)
Diacylglycerol kinase zeta
Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
DGKZ protein
SynonymsDAGK6
DescriptionFUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes . Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species . Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group . The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization . Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). .; FUNCTION: [Isoform 1]: Regulates RASGRP1 activity. .; FUNCTION: [Isoform 2]: Does not regulate RASGRP1 activity. .

AccessionsE9PK94
ENST00000421244.6 [Q13574-4]
ENST00000532868.6 [Q13574-7]
ENST00000524984.5
ENST00000527911.5 [Q13574-5]
ENST00000318201.12 [Q13574-6]
E9PKT3
ENST00000524869.1
ENST00000454345.6 [Q13574-1]
ENST00000343674.10 [Q13574-3]
E9PNZ3
Q7Z5X8
ENST00000524448.1
H0YDN6
ENST00000528615.5
H0YEG2
Q13574
E9PNL8
ENST00000533376.5
ENST00000456247.7 [Q13574-2]
ENST00000525242.5