Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1633.57 | 1445 / 1445 | 100% | 13.02 | 183 / 183 |
| breast | 100% | 2687.16 | 459 / 459 | 100% | 18.01 | 1115 / 1118 |
| brain | 100% | 1912.28 | 2632 / 2642 | 100% | 13.19 | 705 / 705 |
| prostate | 100% | 2225.12 | 245 / 245 | 99% | 9.57 | 499 / 502 |
| lung | 100% | 3261.05 | 578 / 578 | 99% | 10.04 | 1146 / 1155 |
| thymus | 100% | 1899.55 | 653 / 653 | 99% | 11.58 | 596 / 605 |
| uterus | 100% | 2420.04 | 170 / 170 | 98% | 12.76 | 451 / 459 |
| bladder | 100% | 2084.95 | 21 / 21 | 98% | 10.73 | 494 / 504 |
| ovary | 100% | 3037.71 | 180 / 180 | 97% | 7.44 | 419 / 430 |
| kidney | 100% | 1774.30 | 89 / 89 | 96% | 10.87 | 867 / 901 |
| stomach | 100% | 1316.58 | 359 / 359 | 96% | 9.11 | 275 / 286 |
| adrenal gland | 100% | 1860.68 | 258 / 258 | 96% | 8.28 | 220 / 230 |
| pancreas | 98% | 888.93 | 320 / 328 | 98% | 10.35 | 174 / 178 |
| intestine | 100% | 1912.49 | 966 / 966 | 95% | 8.50 | 499 / 527 |
| skin | 100% | 2010.77 | 1809 / 1809 | 92% | 11.85 | 433 / 472 |
| liver | 100% | 974.02 | 226 / 226 | 86% | 5.74 | 348 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 25.85 | 29 / 29 |
| spleen | 100% | 4765.23 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.80 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.04 | 1 / 1 |
| blood vessel | 100% | 1848.61 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2250.73 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1294.12 | 801 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 4590.26 | 916 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 1001.34 | 842 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 68% | 4.13 | 54 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043488 | Biological process | regulation of mRNA stability |
| GO_0006402 | Biological process | mRNA catabolic process |
| GO_0000290 | Biological process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| GO_0071044 | Biological process | histone mRNA catabolic process |
| GO_0000184 | Biological process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| GO_1904872 | Biological process | regulation of telomerase RNA localization to Cajal body |
| GO_0032211 | Biological process | negative regulation of telomere maintenance via telomerase |
| GO_0036464 | Cellular component | cytoplasmic ribonucleoprotein granule |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000932 | Cellular component | P-body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030054 | Cellular component | cell junction |
| GO_0016442 | Cellular component | RISC complex |
| GO_0016896 | Molecular function | RNA exonuclease activity, producing 5'-phosphomonoesters |
| GO_0140933 | Molecular function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| GO_0030145 | Molecular function | manganese ion binding |
| GO_0070034 | Molecular function | telomerase RNA binding |
| GO_0004534 | Molecular function | 5'-3' RNA exonuclease activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DCP2 |
| Protein name | Decapping mRNA 2 (cDNA FLJ52185, highly similar to mRNA decapping enzyme 2) Decapping mRNA 2 DCP2 decapping enzyme homolog (S. cerevisiae), isoform CRA_b (Decapping mRNA 2) m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc) |
| Synonyms | hCG_2042762 NUDT20 |
| Description | FUNCTION: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP . Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Plays a role in replication-dependent histone mRNA degradation . Has higher activity towards mRNAs that lack a poly(A) tail . Has no activity towards a cap structure lacking an RNA moiety . The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts . . |
| Accessions | A0A6Q8PGL6 B7Z3U5 ENST00000389063.3 [Q8IU60-1] ENST00000515408.5 [Q8IU60-2] A0A6Q8PGI4 Q8IU60 ENST00000674880.1 ENST00000513585.6 ENST00000502635.2 |
