CXADR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0086067Biological processAV node cell to bundle of His cell communication
GO_0010669Biological processepithelial structure maintenance
GO_0007507Biological processheart development
GO_0070633Biological processtransepithelial transport
GO_0055013Biological processcardiac muscle cell development
GO_0046629Biological processgamma-delta T cell activation
GO_0098904Biological processregulation of AV node cell action potential
GO_0030593Biological processneutrophil chemotaxis
GO_0045216Biological processcell-cell junction organization
GO_0034109Biological processhomotypic cell-cell adhesion
GO_0030036Biological processactin cytoskeleton organization
GO_0046718Biological processsymbiont entry into host cell
GO_0086072Biological processAV node cell-bundle of His cell adhesion involved in cell communication
GO_0007005Biological processmitochondrion organization
GO_0008354Biological processgerm cell migration
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0001669Cellular componentacrosomal vesicle
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0005911Cellular componentcell-cell junction
GO_0030175Cellular componentfilopodium
GO_0005912Cellular componentadherens junction
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0044297Cellular componentcell body
GO_0030054Cellular componentcell junction
GO_0016327Cellular componentapicolateral plasma membrane
GO_0014704Cellular componentintercalated disc
GO_0016323Cellular componentbasolateral plasma membrane
GO_0071253Molecular functionconnexin binding
GO_0008013Molecular functionbeta-catenin binding
GO_0001618Molecular functionvirus receptor activity
GO_0005178Molecular functionintegrin binding
GO_0030165Molecular functionPDZ domain binding
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005515Molecular functionprotein binding
GO_0086082Molecular functioncell adhesive protein binding involved in AV node cell-bundle of His cell communication

IV. Literature review

[source]
Gene nameCXADR
Protein nameCoxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)
SynonymsCAR
DescriptionFUNCTION: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. .; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. .; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. .

AccessionsENST00000356275.10 [P78310-3]
ENST00000400165.5 [P78310-4]
ENST00000284878.12 [P78310-1]
ENST00000400166.5 [P78310-5]
ENST00000400169.1 [P78310-6]
P78310