CUEDC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	14 studies	26% ± 9%	Explore
endothelial cell	11 studies	25% ± 11%	Explore
smooth muscle cell	11 studies	25% ± 7%	Explore
classical monocyte	9 studies	23% ± 9%	Explore
pericyte	9 studies	26% ± 9%	Explore
myofibroblast cell	8 studies	26% ± 8%	Explore
connective tissue cell	8 studies	29% ± 8%	Explore
CD8-positive, alpha-beta T cell	8 studies	21% ± 4%	Explore
natural killer cell	7 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 2%	Explore
epithelial cell	6 studies	33% ± 14%	Explore
neuron	6 studies	42% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
ciliated cell	5 studies	28% ± 7%	Explore
regulatory T cell	5 studies	20% ± 3%	Explore
hematopoietic precursor cell	4 studies	32% ± 11%	Explore
conventional dendritic cell	4 studies	34% ± 16%	Explore
exhausted T cell	4 studies	22% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
retinal ganglion cell	4 studies	63% ± 24%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
oligodendrocyte precursor cell	4 studies	32% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	18% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 0%	Explore
non-classical monocyte	3 studies	28% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 2%	Explore
endothelial cell of artery	3 studies	16% ± 1%	Explore
neural crest cell	3 studies	45% ± 17%	Explore
endothelial cell of lymphatic vessel	3 studies	28% ± 7%	Explore
mesothelial cell	3 studies	38% ± 15%	Explore
precursor B cell	3 studies	19% ± 2%	Explore
type I pneumocyte	3 studies	22% ± 4%	Explore
retina horizontal cell	3 studies	34% ± 15%	Explore
retinal rod cell	3 studies	19% ± 4%	Explore
monocyte	3 studies	19% ± 3%	Explore
endothelial cell of vascular tree	3 studies	18% ± 1%	Explore
macrophage	3 studies	21% ± 4%	Explore
glutamatergic neuron	3 studies	30% ± 8%	Explore
dendritic cell	3 studies	42% ± 11%	Explore
enteroendocrine cell	3 studies	28% ± 15%	Explore
basal cell	3 studies	34% ± 12%	Explore
oligodendrocyte	3 studies	22% ± 3%	Explore
hematopoietic stem cell	3 studies	22% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	21% ± 7%	Explore
lung	5 studies	29% ± 9%	Explore
eye	4 studies	25% ± 8%	Explore
intestine	3 studies	25% ± 13%	Explore
brain	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3323.59	2642 / 2642	100%	240.41	705 / 705
ovary	100%	3018.51	180 / 180	100%	127.61	430 / 430
thymus	100%	2635.67	653 / 653	100%	157.50	604 / 605
uterus	100%	2999.74	170 / 170	100%	136.00	458 / 459
skin	100%	2538.42	1808 / 1809	100%	130.78	471 / 472
kidney	100%	2816.89	89 / 89	100%	127.43	897 / 901
liver	100%	1372.01	226 / 226	100%	88.37	404 / 406
esophagus	100%	2606.42	1445 / 1445	99%	64.62	182 / 183
stomach	100%	2171.88	359 / 359	99%	82.82	284 / 286
prostate	100%	2920.45	245 / 245	99%	168.82	498 / 502
pancreas	100%	1316.91	327 / 328	99%	102.04	177 / 178
adrenal gland	100%	3583.13	258 / 258	99%	147.43	228 / 230
lung	100%	2261.65	577 / 578	99%	95.64	1146 / 1155
intestine	100%	2801.19	966 / 966	99%	91.95	521 / 527
breast	100%	2529.68	459 / 459	99%	123.85	1104 / 1118
bladder	100%	2732.62	21 / 21	98%	107.95	495 / 504
adipose	100%	2527.74	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	180.49	80 / 80
lymph node	0%	0	0 / 0	100%	192.93	29 / 29
muscle	100%	3216.03	803 / 803	0%	0	0 / 0
spleen	100%	2627.83	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	112.25	45 / 45
ureter	0%	0	0 / 0	100%	55.05	1 / 1
blood vessel	100%	2598.64	1333 / 1335	0%	0	0 / 0
heart	99%	2965.83	854 / 861	0%	0	0 / 0
peripheral blood	95%	1944.74	880 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010936	Biological process	negative regulation of macrophage cytokine production
GO_1900016	Biological process	negative regulation of cytokine production involved in inflammatory response
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0031965	Cellular component	nuclear membrane
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	CUEDC2
Protein name	CUE domain-containing protein 2
Synonyms	HOYS6 C10orf66
Description	FUNCTION: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. .
Accessions	ENST00000369937.5 Q9H467

CUEDC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review