Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 3314.81 | 21 / 21 | 100% | 50.54 | 504 / 504 |
| esophagus | 100% | 3051.44 | 1445 / 1445 | 100% | 34.62 | 183 / 183 |
| lung | 100% | 5800.59 | 578 / 578 | 100% | 55.66 | 1155 / 1155 |
| ovary | 100% | 2974.10 | 180 / 180 | 100% | 48.96 | 430 / 430 |
| stomach | 100% | 2580.44 | 359 / 359 | 100% | 42.69 | 286 / 286 |
| uterus | 100% | 3224.90 | 170 / 170 | 100% | 54.38 | 459 / 459 |
| breast | 100% | 5332.18 | 459 / 459 | 100% | 66.87 | 1117 / 1118 |
| intestine | 100% | 3848.17 | 966 / 966 | 100% | 52.39 | 526 / 527 |
| thymus | 100% | 4180.69 | 653 / 653 | 100% | 59.76 | 603 / 605 |
| brain | 100% | 2386.79 | 2631 / 2642 | 100% | 60.21 | 705 / 705 |
| prostate | 100% | 3094.29 | 245 / 245 | 99% | 46.51 | 499 / 502 |
| kidney | 100% | 2317.47 | 89 / 89 | 98% | 43.09 | 887 / 901 |
| adrenal gland | 100% | 4301.10 | 258 / 258 | 98% | 41.27 | 225 / 230 |
| skin | 100% | 4359.47 | 1809 / 1809 | 94% | 36.35 | 446 / 472 |
| liver | 99% | 1328.20 | 224 / 226 | 95% | 22.51 | 387 / 406 |
| pancreas | 95% | 1328.52 | 310 / 328 | 99% | 49.97 | 176 / 178 |
| adipose | 100% | 5842.71 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4809.55 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 54.86 | 29 / 29 |
| spleen | 100% | 5048.51 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 50.99 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.35 | 1 / 1 |
| peripheral blood | 99% | 4018.00 | 917 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 1833.69 | 845 / 861 | 0% | 0 | 0 / 0 |
| muscle | 94% | 1357.39 | 758 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 18.37 | 60 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000289 | Biological process | nuclear-transcribed mRNA poly(A) tail shortening |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0000288 | Biological process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO_0061014 | Biological process | positive regulation of mRNA catabolic process |
| GO_0035279 | Biological process | miRNA-mediated gene silencing by mRNA destabilization |
| GO_0006417 | Biological process | regulation of translation |
| GO_0000932 | Cellular component | P-body |
| GO_0030014 | Cellular component | CCR4-NOT complex |
| GO_0030015 | Cellular component | CCR4-NOT core complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0000175 | Molecular function | 3'-5'-RNA exonuclease activity |
| GO_0004535 | Molecular function | poly(A)-specific ribonuclease activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | CNOT8 |
| Protein name | CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b) CCR4-NOT transcription complex subunit 8 poly(A)-specific ribonuclease (EC 3.1.13.4) |
| Synonyms | CALIF POP2 |
| Description | FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. . |
| Accessions | ENST00000519430.5 E5RIU0 ENST00000520472.5 ENST00000521583.5 [Q9UFF9-2] ENST00000521729.5 ENST00000524105.5 Q9UFF9 E5RHD6 E5RHL9 ENST00000520671.5 [Q9UFF9-2] ENST00000517568.5 ENST00000519211.5 ENST00000522458.5 E5RGE4 E5RHG0 ENST00000519903.5 ENST00000518028.5 ENST00000519404.5 [Q9UFF9-3] E5RFJ4 ENST00000403027.6 [Q9UFF9-1] E5RIL2 ENST00000522644.5 ENST00000517876.5 [Q9UFF9-1] ENST00000521450.5 [Q9UFF9-2] ENST00000285896.11 [Q9UFF9-1] ENST00000523698.5 [Q9UFF9-2] E5RHP3 ENST00000519394.5 B7Z9U0 ENST00000518775.5 E5RJC5 |
