CLIC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0001525Biological processangiogenesis
GO_0006821Biological processchloride transport
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0061299Biological processretina vasculature morphogenesis in camera-type eye
GO_0051493Biological processregulation of cytoskeleton organization
GO_0035264Biological processmulticellular organism growth
GO_0071277Biological processcellular response to calcium ion
GO_0009566Biological processfertilization
GO_1902476Biological processchloride transmembrane transport
GO_0030154Biological processcell differentiation
GO_0007035Biological processvacuolar acidification
GO_0035088Biological processestablishment or maintenance of apical/basal cell polarity
GO_0030336Biological processnegative regulation of cell migration
GO_0001886Biological processendothelial cell morphogenesis
GO_0005902Cellular componentmicrovillus
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005911Cellular componentcell-cell junction
GO_0016363Cellular componentnuclear matrix
GO_0009986Cellular componentcell surface
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0034707Cellular componentchloride channel complex
GO_0005737Cellular componentcytoplasm
GO_0045177Cellular componentapical part of cell
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005515Molecular functionprotein binding
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameCLIC4
Protein nameChloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1)
Chloride intracellular channel protein
SynonymshCG_24047
DescriptionFUNCTION: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). .

AccessionsENST00000374379.9
Q9Y696
Q6FIC5
ENST00000488683.1