CISD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	21 studies	24% ± 8%	Explore
plasma cell	11 studies	38% ± 11%	Explore
plasmablast	9 studies	36% ± 22%	Explore
erythrocyte	8 studies	34% ± 21%	Explore
CD8-positive, alpha-beta T cell	8 studies	21% ± 3%	Explore
myeloid cell	7 studies	22% ± 6%	Explore
epithelial cell	7 studies	39% ± 14%	Explore
regulatory T cell	7 studies	21% ± 3%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 9%	Explore
CD4-positive, alpha-beta T cell	6 studies	25% ± 3%	Explore
conventional dendritic cell	6 studies	25% ± 7%	Explore
T cell	6 studies	20% ± 4%	Explore
monocyte	6 studies	21% ± 6%	Explore
epithelial cell of proximal tubule	5 studies	24% ± 4%	Explore
erythroblast	5 studies	38% ± 24%	Explore
natural killer cell	5 studies	23% ± 5%	Explore
endothelial cell	5 studies	23% ± 9%	Explore
ciliated cell	5 studies	31% ± 9%	Explore
hematopoietic precursor cell	4 studies	26% ± 7%	Explore
pancreatic A cell	4 studies	39% ± 9%	Explore
mononuclear phagocyte	4 studies	23% ± 11%	Explore
retinal ganglion cell	4 studies	48% ± 28%	Explore
abnormal cell	4 studies	21% ± 3%	Explore
neuron	4 studies	31% ± 14%	Explore
deuterosomal cell	3 studies	19% ± 5%	Explore
type B pancreatic cell	3 studies	56% ± 4%	Explore
classical monocyte	3 studies	18% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	18% ± 2%	Explore
B cell	3 studies	23% ± 6%	Explore
IgA plasma cell	3 studies	19% ± 1%	Explore
IgG plasma cell	3 studies	22% ± 3%	Explore
retina horizontal cell	3 studies	24% ± 7%	Explore
retinal cone cell	3 studies	47% ± 13%	Explore
retinal rod cell	3 studies	25% ± 7%	Explore
fibroblast	3 studies	27% ± 9%	Explore
GABAergic neuron	3 studies	29% ± 7%	Explore
glutamatergic neuron	3 studies	35% ± 11%	Explore
dendritic cell	3 studies	34% ± 12%	Explore
non-classical monocyte	3 studies	22% ± 2%	Explore
pancreatic ductal cell	3 studies	36% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	34% ± 24%	Explore
goblet cell	3 studies	27% ± 9%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
basal cell	3 studies	37% ± 10%	Explore
gamma-delta T cell	3 studies	28% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	5 studies	17% ± 2%	Explore
brain	5 studies	23% ± 7%	Explore
peripheral blood	4 studies	18% ± 2%	Explore
eye	4 studies	25% ± 9%	Explore
lung	4 studies	30% ± 8%	Explore
liver	4 studies	36% ± 29%	Explore
pancreas	3 studies	47% ± 5%	Explore
intestine	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	713.21	459 / 459	100%	13.34	1118 / 1118
intestine	100%	786.94	966 / 966	100%	12.38	527 / 527
kidney	100%	1212.25	89 / 89	100%	15.95	901 / 901
liver	100%	1721.18	226 / 226	100%	13.42	406 / 406
ovary	100%	661.24	180 / 180	100%	12.65	430 / 430
pancreas	100%	824.59	328 / 328	100%	11.36	178 / 178
prostate	100%	802.37	245 / 245	100%	11.61	502 / 502
stomach	100%	665.11	359 / 359	100%	11.92	286 / 286
uterus	100%	722.70	170 / 170	100%	15.28	459 / 459
brain	100%	1293.61	2641 / 2642	100%	11.11	705 / 705
esophagus	100%	621.05	1444 / 1445	100%	12.24	183 / 183
thymus	100%	1110.75	653 / 653	100%	13.19	604 / 605
bladder	100%	720.57	21 / 21	100%	12.26	503 / 504
skin	100%	865.13	1806 / 1809	100%	12.32	471 / 472
adrenal gland	100%	1362.52	258 / 258	100%	14.70	229 / 230
lung	99%	812.60	575 / 578	100%	12.70	1155 / 1155
eye	0%	0	0 / 0	100%	8.55	80 / 80
lymph node	0%	0	0 / 0	100%	11.57	29 / 29
spleen	100%	1024.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	13.81	45 / 45
ureter	0%	0	0 / 0	100%	7.02	1 / 1
adipose	100%	711.37	1202 / 1204	0%	0	0 / 0
blood vessel	100%	700.22	1331 / 1335	0%	0	0 / 0
muscle	97%	331.92	780 / 803	0%	0	0 / 0
heart	96%	547.86	829 / 861	0%	0	0 / 0
peripheral blood	92%	680.15	854 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000422	Biological process	autophagy of mitochondrion
GO_0006914	Biological process	autophagy
GO_0010506	Biological process	regulation of autophagy
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0097038	Cellular component	perinuclear endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0051537	Molecular function	2 iron, 2 sulfur cluster binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	CISD2
Protein name	CDGSH iron-sulfur domain-containing protein 2 CDGSH iron sulfur domain 2 CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)
Synonyms	ZCD2 ERIS CDGSH2
Description	FUNCTION: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. . FUNCTION: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. .
Accessions	ENST00000503643.1 ENST00000643561.1 I3L1N9 D6RCF4 A0A2R8Y4Y3 ENST00000273986.10 ENST00000574446.1 Q8N5K1 A0A2R8Y540 ENST00000646632.1

CISD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review