CHIC2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	27% ± 10%	Explore
natural killer cell	21 studies	21% ± 5%	Explore
fibroblast	21 studies	27% ± 10%	Explore
regulatory T cell	13 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	11 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	11 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 7%	Explore
gamma-delta T cell	9 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	19% ± 2%	Explore
mature NK T cell	8 studies	20% ± 3%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 14%	Explore
mucosal invariant T cell	8 studies	21% ± 4%	Explore
ciliated cell	8 studies	30% ± 11%	Explore
endothelial cell of vascular tree	8 studies	30% ± 11%	Explore
macrophage	8 studies	24% ± 8%	Explore
T cell	8 studies	20% ± 4%	Explore
classical monocyte	7 studies	21% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	23% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	20% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	19% ± 5%	Explore
microglial cell	6 studies	25% ± 7%	Explore
connective tissue cell	6 studies	22% ± 5%	Explore
epithelial cell	6 studies	38% ± 16%	Explore
endothelial cell of artery	6 studies	24% ± 4%	Explore
vein endothelial cell	6 studies	31% ± 15%	Explore
basal cell	6 studies	31% ± 13%	Explore
endothelial cell of lymphatic vessel	6 studies	29% ± 10%	Explore
astrocyte	6 studies	30% ± 11%	Explore
leukocyte	5 studies	19% ± 3%	Explore
naive B cell	5 studies	19% ± 4%	Explore
lymphocyte	5 studies	28% ± 9%	Explore
T follicular helper cell	5 studies	21% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 6%	Explore
myeloid cell	4 studies	22% ± 3%	Explore
GABAergic neuron	4 studies	40% ± 11%	Explore
B cell	4 studies	18% ± 2%	Explore
myofibroblast cell	4 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	17% ± 1%	Explore
non-classical monocyte	3 studies	23% ± 4%	Explore
precursor B cell	3 studies	26% ± 3%	Explore
pro-B cell	3 studies	23% ± 1%	Explore
mononuclear phagocyte	3 studies	21% ± 1%	Explore
abnormal cell	3 studies	21% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
innate lymphoid cell	3 studies	22% ± 3%	Explore
hepatocyte	3 studies	39% ± 23%	Explore
glutamatergic neuron	3 studies	56% ± 6%	Explore
monocyte	3 studies	21% ± 1%	Explore
smooth muscle cell	3 studies	17% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 6%	Explore
neuron	3 studies	27% ± 6%	Explore
oligodendrocyte	3 studies	20% ± 3%	Explore
secretory cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	19% ± 3%	Explore
lung	5 studies	20% ± 3%	Explore
brain	5 studies	36% ± 13%	Explore
liver	3 studies	27% ± 6%	Explore
adipose	3 studies	18% ± 2%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	786.52	1445 / 1445	100%	34.36	183 / 183
ovary	100%	640.66	180 / 180	100%	29.87	430 / 430
prostate	100%	704.86	245 / 245	100%	36.86	502 / 502
uterus	100%	675.82	170 / 170	100%	46.60	459 / 459
breast	100%	936.97	459 / 459	100%	34.79	1117 / 1118
lung	100%	1021.90	577 / 578	100%	43.08	1155 / 1155
intestine	100%	635.59	966 / 966	100%	32.70	526 / 527
bladder	100%	733.33	21 / 21	100%	38.27	503 / 504
stomach	100%	469.77	358 / 359	100%	30.07	285 / 286
thymus	100%	671.69	652 / 653	99%	35.03	601 / 605
liver	100%	525.31	226 / 226	98%	19.57	399 / 406
adrenal gland	100%	749.35	258 / 258	98%	24.13	226 / 230
skin	100%	1292.66	1808 / 1809	98%	27.00	464 / 472
kidney	100%	598.90	89 / 89	98%	27.47	885 / 901
pancreas	92%	277.24	302 / 328	99%	45.53	177 / 178
brain	91%	263.13	2396 / 2642	100%	43.52	705 / 705
lymph node	0%	0	0 / 0	100%	34.36	29 / 29
spleen	100%	875.87	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	45.31	45 / 45
ureter	0%	0	0 / 0	100%	19.66	1 / 1
peripheral blood	100%	1483.25	927 / 929	0%	0	0 / 0
adipose	100%	973.88	1201 / 1204	0%	0	0 / 0
blood vessel	100%	720.67	1331 / 1335	0%	0	0 / 0
heart	95%	447.17	820 / 861	0%	0	0 / 0
muscle	89%	275.87	713 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	76%	10.08	61 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0