CHD6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0045454Biological processcell redox homeostasis
GO_0010468Biological processregulation of gene expression
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0001221Molecular functiontranscription coregulator binding
GO_0003677Molecular functionDNA binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0004386Molecular functionhelicase activity
GO_0005524Molecular functionATP binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameCHD6
Protein nameChromodomain helicase DNA binding protein 6
Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)
DNA helicase (EC 3.6.4.12)
SynonymsCHD5
RIGB
KIAA1335
DescriptionFUNCTION: DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin . Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. .; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. .

AccessionsENST00000440697.5
H7C294
ENST00000373222.3 [Q8TD26-2]
ENST00000440647.1
A0A075B6P4
ENST00000373233.8 [Q8TD26-1]
Q8TD26