CENPX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0031297Biological processreplication fork processing
GO_0051301Biological processcell division
GO_0036297Biological processinterstrand cross-link repair
GO_0007059Biological processchromosome segregation
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0051382Biological processkinetochore assembly
GO_0043240Cellular componentFanconi anaemia nuclear complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0071821Cellular componentFANCM-MHF complex
GO_0000939Cellular componentinner kinetochore
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCENPX
Protein nameCentromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog)
Centromere protein X
SynonymsMHF2
STRA13
FAAP10
DescriptionFUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage . In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks . In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression . As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure . DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own . .

AccessionsENST00000584600.5
ENST00000584347.1
ENST00000392359.8 [A8MT69-1]
ENST00000580435.5 [A8MT69-3]
J3QR01
ENST00000579520.5
A8MT69
J3QRS1
J3QR35
ENST00000306704.10 [A8MT69-2]