CDK5RAP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045664Biological processregulation of neuron differentiation
GO_1901798Biological processpositive regulation of signal transduction by p53 class mediator
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0008283Biological processcell population proliferation
GO_0010921Biological processregulation of phosphatase activity
GO_0044387Biological processnegative regulation of protein kinase activity by regulation of protein phosphorylation
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0140501Biological processpositive regulation of reticulophagy
GO_0001889Biological processliver development
GO_0030262Biological processapoptotic nuclear changes
GO_0072344Biological processrescue of stalled ribosome
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0032790Biological processribosome disassembly
GO_0071569Biological processprotein ufmylation
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0007346Biological processregulation of mitotic cell cycle
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0007420Biological processbrain development
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0060318Biological processdefinitive erythrocyte differentiation
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0005730Cellular componentnucleolus
GO_0005874Cellular componentmicrotubule
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0051059Molecular functionNF-kappaB binding
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0097371Molecular functionMDM2/MDM4 family protein binding
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding
GO_0044389Molecular functionubiquitin-like protein ligase binding

IV. Literature review

[source]
Gene nameCDK5RAP3
Protein nameCDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)
CDK5 regulatory subunit associated protein 3
SynonymsIC53
PP1553
LZAP
OK/SW-cl.114
MSTP016
DescriptionFUNCTION: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress . Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation . Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation . Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint . Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation . May also play a role in the rupture of the nuclear envelope during apoptosis . May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 . Required for liver development (By similarity). .; FUNCTION: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry. .

AccessionsJ3QL95
ENST00000579632.5
ENST00000583352.5
J3QQS7
ENST00000580391.5
J3QL86
ENST00000578018.5
ENST00000583697.1
J3KSD0
ENST00000580670.6
ENST00000579175.5
J3KRK4
J3KS63
ENST00000583363.5
ENST00000578525.5
J3QRX0
ENST00000584991.5
J3QRM1
ENST00000536708.6 [Q96JB5-4]
ENST00000338399.9 [Q96JB5-1]
J3KRI2
J3QQY1
ENST00000579605.5
J3KTA5
J3QS62
ENST00000577664.5
Q96JB5