CDK12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006397Biological processmRNA processing
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0008380Biological processRNA splicing
GO_0043405Biological processregulation of MAP kinase activity
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0002944Cellular componentcyclin K-CDK12 complex
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0019908Cellular componentnuclear cyclin-dependent protein kinase holoenzyme complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004672Molecular functionprotein kinase activity
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameCDK12
Protein nameCyclin dependent kinase 12
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
Cyclin-dependent kinase 12
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 12)
SynonymsCRKRS
CRK7
KIAA0904
DescriptionFUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. .

AccessionsJ3QSD7
ENST00000447079.6 [Q9NYV4-1]
ENST00000559663.2
ENST00000581593.1
ENST00000584632.5
H0YLT2
Q9NYV4
A0A2I6PNI6
A0A590UJE9
ENST00000430627.6 [Q9NYV4-2]