CAVIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006363Biological processtermination of RNA polymerase I transcription
GO_0006361Biological processtranscription initiation at RNA polymerase I promoter
GO_2000147Biological processpositive regulation of cell motility
GO_0009303Biological processrRNA transcription
GO_0009306Biological processprotein secretion
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005901Cellular componentcaveola
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0042134Molecular functionrRNA primary transcript binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAVIN1
Protein nameCaveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)
SynonymsFKSG13
PTRF
DescriptionFUNCTION: Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues . Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) . The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). .

AccessionsENST00000357037.6 [Q6NZI2-1]
Q6NZI2