Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 24 studies | 39% ± 16% | |
B cell | 21 studies | 30% ± 13% | |
astrocyte | 19 studies | 42% ± 17% | |
fibroblast | 19 studies | 41% ± 16% | |
pericyte | 17 studies | 39% ± 18% | |
oligodendrocyte precursor cell | 16 studies | 44% ± 17% | |
microglial cell | 16 studies | 51% ± 17% | |
naive B cell | 16 studies | 28% ± 8% | |
macrophage | 12 studies | 32% ± 15% | |
oligodendrocyte | 12 studies | 36% ± 13% | |
smooth muscle cell | 12 studies | 38% ± 14% | |
GABAergic neuron | 11 studies | 50% ± 21% | |
glutamatergic neuron | 11 studies | 57% ± 16% | |
adipocyte | 10 studies | 49% ± 13% | |
epithelial cell | 9 studies | 38% ± 13% | |
ciliated cell | 9 studies | 31% ± 14% | |
endothelial cell of lymphatic vessel | 9 studies | 43% ± 17% | |
T cell | 8 studies | 30% ± 12% | |
club cell | 8 studies | 39% ± 18% | |
neuron | 7 studies | 46% ± 23% | |
goblet cell | 7 studies | 31% ± 12% | |
retinal ganglion cell | 7 studies | 57% ± 20% | |
basal cell | 7 studies | 31% ± 14% | |
dendritic cell | 7 studies | 31% ± 12% | |
retinal cone cell | 7 studies | 64% ± 27% | |
retinal rod cell | 7 studies | 52% ± 31% | |
myeloid cell | 7 studies | 35% ± 12% | |
abnormal cell | 6 studies | 33% ± 19% | |
interneuron | 6 studies | 58% ± 20% | |
retina horizontal cell | 6 studies | 46% ± 23% | |
cardiac muscle cell | 6 studies | 75% ± 18% | |
mesothelial cell | 6 studies | 37% ± 15% | |
Mueller cell | 6 studies | 40% ± 20% | |
type I pneumocyte | 6 studies | 40% ± 12% | |
type II pneumocyte | 6 studies | 46% ± 12% | |
regulatory T cell | 6 studies | 27% ± 10% | |
retinal bipolar neuron | 5 studies | 49% ± 26% | |
brush cell | 5 studies | 45% ± 14% | |
amacrine cell | 5 studies | 44% ± 21% | |
conventional dendritic cell | 5 studies | 21% ± 6% | |
monocyte | 5 studies | 34% ± 8% | |
granule cell | 4 studies | 53% ± 21% | |
precursor B cell | 4 studies | 36% ± 9% | |
immature B cell | 4 studies | 36% ± 8% | |
CD4-positive, alpha-beta T cell | 4 studies | 29% ± 7% | |
lymphocyte | 4 studies | 37% ± 15% | |
OFF-bipolar cell | 4 studies | 55% ± 17% | |
ON-bipolar cell | 4 studies | 49% ± 19% | |
endothelial cell of artery | 4 studies | 24% ± 8% | |
endothelial cell of vascular tree | 4 studies | 35% ± 19% | |
hepatocyte | 4 studies | 56% ± 15% | |
connective tissue cell | 4 studies | 37% ± 14% | |
respiratory goblet cell | 4 studies | 46% ± 20% | |
myofibroblast cell | 4 studies | 34% ± 19% | |
cholangiocyte | 3 studies | 50% ± 21% | |
hepatic stellate cell | 3 studies | 50% ± 18% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 5% | |
GABAergic interneuron | 3 studies | 48% ± 5% | |
Purkinje cell | 3 studies | 59% ± 26% | |
glial cell | 3 studies | 34% ± 12% | |
progenitor cell | 3 studies | 37% ± 8% | |
memory B cell | 3 studies | 20% ± 3% | |
mucosal invariant T cell | 3 studies | 27% ± 9% | |
CD8-positive, alpha-beta T cell | 3 studies | 26% ± 7% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 27% ± 9% | |
endocardial cell | 3 studies | 40% ± 15% | |
mononuclear phagocyte | 3 studies | 27% ± 9% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 24% ± 7% | |
vein endothelial cell | 3 studies | 42% ± 17% | |
GABAergic amacrine cell | 3 studies | 45% ± 15% | |
glycinergic amacrine cell | 3 studies | 42% ± 8% | |
rod bipolar cell | 3 studies | 77% ± 18% | |
ependymal cell | 3 studies | 51% ± 20% | |
enteroendocrine cell | 3 studies | 31% ± 10% | |
leukocyte | 3 studies | 43% ± 18% | |
alveolar macrophage | 3 studies | 49% ± 8% | |
capillary endothelial cell | 3 studies | 27% ± 5% | |
natural killer cell | 3 studies | 34% ± 5% | |
muscle cell | 3 studies | 43% ± 6% | |
mural cell | 3 studies | 51% ± 3% | |
mucus secreting cell | 3 studies | 32% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3860.68 | 1445 / 1445 | 99% | 31.66 | 182 / 183 |
thymus | 100% | 3319.91 | 652 / 653 | 99% | 30.48 | 601 / 605 |
prostate | 100% | 3793.38 | 244 / 245 | 99% | 26.66 | 499 / 502 |
lung | 100% | 4662.63 | 576 / 578 | 99% | 28.58 | 1147 / 1155 |
stomach | 100% | 3510.00 | 359 / 359 | 99% | 22.94 | 283 / 286 |
intestine | 100% | 4932.37 | 966 / 966 | 99% | 24.65 | 520 / 527 |
brain | 96% | 5057.30 | 2540 / 2642 | 100% | 55.90 | 704 / 705 |
uterus | 100% | 3534.62 | 170 / 170 | 95% | 21.52 | 438 / 459 |
breast | 100% | 4532.43 | 459 / 459 | 94% | 21.97 | 1054 / 1118 |
skin | 100% | 3941.50 | 1807 / 1809 | 94% | 24.74 | 445 / 472 |
bladder | 100% | 5288.57 | 21 / 21 | 94% | 19.12 | 474 / 504 |
adrenal gland | 98% | 3255.91 | 252 / 258 | 93% | 15.42 | 215 / 230 |
liver | 94% | 1721.15 | 213 / 226 | 92% | 13.21 | 375 / 406 |
kidney | 88% | 1542.15 | 78 / 89 | 98% | 22.66 | 882 / 901 |
ovary | 100% | 3039.06 | 180 / 180 | 70% | 7.02 | 302 / 430 |
pancreas | 61% | 801.15 | 199 / 328 | 98% | 25.91 | 175 / 178 |
adipose | 100% | 5802.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5342.82 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 27.79 | 29 / 29 |
muscle | 100% | 8973.35 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2050.18 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.46 | 1 / 1 |
heart | 97% | 9320.37 | 838 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 19.22 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 68% | 7.87 | 54 / 80 |
peripheral blood | 34% | 1533.16 | 316 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_1902514 | Biological process | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
GO_0098909 | Biological process | regulation of cardiac muscle cell action potential involved in regulation of contraction |
GO_0001558 | Biological process | regulation of cell growth |
GO_0010613 | Biological process | positive regulation of cardiac muscle hypertrophy |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_1901897 | Biological process | regulation of relaxation of cardiac muscle |
GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
GO_0002026 | Biological process | regulation of the force of heart contraction |
GO_0010666 | Biological process | positive regulation of cardiac muscle cell apoptotic process |
GO_1902306 | Biological process | negative regulation of sodium ion transmembrane transport |
GO_0055119 | Biological process | relaxation of cardiac muscle |
GO_0086003 | Biological process | cardiac muscle cell contraction |
GO_0060341 | Biological process | regulation of cellular localization |
GO_0003254 | Biological process | regulation of membrane depolarization |
GO_0010881 | Biological process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
GO_0071277 | Biological process | cellular response to calcium ion |
GO_0098901 | Biological process | regulation of cardiac muscle cell action potential |
GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
GO_0010649 | Biological process | regulation of cell communication by electrical coupling |
GO_0010880 | Biological process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
GO_0006468 | Biological process | protein phosphorylation |
GO_0046777 | Biological process | protein autophosphorylation |
GO_2000650 | Biological process | negative regulation of sodium ion transmembrane transporter activity |
GO_1901844 | Biological process | regulation of cell communication by electrical coupling involved in cardiac conduction |
GO_0060314 | Biological process | regulation of ryanodine-sensitive calcium-release channel activity |
GO_0008016 | Biological process | regulation of heart contraction |
GO_0032469 | Biological process | endoplasmic reticulum calcium ion homeostasis |
GO_0016020 | Cellular component | membrane |
GO_0030666 | Cellular component | endocytic vesicle membrane |
GO_0005954 | Cellular component | calcium- and calmodulin-dependent protein kinase complex |
GO_0042383 | Cellular component | sarcolemma |
GO_0005654 | Cellular component | nucleoplasm |
GO_0043005 | Cellular component | neuron projection |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0031432 | Molecular function | titin binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0019871 | Molecular function | sodium channel inhibitor activity |
GO_0044325 | Molecular function | transmembrane transporter binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CAMK2D |
Protein name | Calcium/calmodulin dependent protein kinase II delta Calcium/calmodulin-dependent protein kinase type II subunit delta (EC 2.7.11.17) CAMK2D protein calcium/calmodulin-dependent protein kinase (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase type II subunit delta |
Synonyms | CAMKD hCG_22679 |
Description | FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program . Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis . May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). . |
Accessions | Q13557 ENST00000699372.1 ENST00000699416.1 A0A8V8TPM4 A0A8V8TN60 ENST00000706057.1 E9PBG7 E9PF82 A0A8V8TPY4 ENST00000699378.1 A0A8V8TNA1 A0A994J7X8 H0Y9C2 ENST00000699381.1 [Q13557-6] A0A8V8TNA7 A0A8V8TPJ8 ENST00000706055.1 ENST00000699374.1 ENST00000699382.1 ENST00000699376.1 A0A8V8TN88 ENST00000515496.5 [Q13557-3] ENST00000699377.1 ENST00000508738.5 [Q13557-9] A0A8V8TNN4 ENST00000379773.6 [Q13557-8] A0A8V8TPK3 ENST00000699418.1 A0A994J516 ENST00000505990.5 A0A8V8TNR6 ENST00000699379.1 ENST00000699373.1 ENST00000699380.1 ENST00000296402.9 [Q13557-8] A0A8V8TQ10 H0Y9J2 ENST00000699419.1 ENST00000509594.1 ENST00000699047.1 [Q13557-6] ENST00000513132.5 ENST00000699421.1 D6R938 A0A8V8TND4 ENST00000394522.7 [Q13557-10] Q4G1A8 A0A994J5B0 ENST00000683023.1 [Q13557-1] ENST00000699375.1 ENST00000394524.7 [Q13557-12] ENST00000342666.9 [Q13557-1] A0A8V8TN65 ENST00000511664.6 ENST00000514328.5 ENST00000706056.1 A0A8V8TNN9 ENST00000699048.1 [Q13557-11] ENST00000699417.1 |