CAMK2D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1902514Biological processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0098909Biological processregulation of cardiac muscle cell action potential involved in regulation of contraction
GO_0001558Biological processregulation of cell growth
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1901897Biological processregulation of relaxation of cardiac muscle
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0002026Biological processregulation of the force of heart contraction
GO_0010666Biological processpositive regulation of cardiac muscle cell apoptotic process
GO_1902306Biological processnegative regulation of sodium ion transmembrane transport
GO_0055119Biological processrelaxation of cardiac muscle
GO_0086003Biological processcardiac muscle cell contraction
GO_0060341Biological processregulation of cellular localization
GO_0003254Biological processregulation of membrane depolarization
GO_0010881Biological processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0071277Biological processcellular response to calcium ion
GO_0098901Biological processregulation of cardiac muscle cell action potential
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0010649Biological processregulation of cell communication by electrical coupling
GO_0010880Biological processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_2000650Biological processnegative regulation of sodium ion transmembrane transporter activity
GO_1901844Biological processregulation of cell communication by electrical coupling involved in cardiac conduction
GO_0060314Biological processregulation of ryanodine-sensitive calcium-release channel activity
GO_0008016Biological processregulation of heart contraction
GO_0032469Biological processendoplasmic reticulum calcium ion homeostasis
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005954Cellular componentcalcium- and calmodulin-dependent protein kinase complex
GO_0042383Cellular componentsarcolemma
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0031432Molecular functiontitin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0019871Molecular functionsodium channel inhibitor activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAMK2D
Protein nameCalcium/calmodulin dependent protein kinase II delta
Calcium/calmodulin-dependent protein kinase type II subunit delta (EC 2.7.11.17)
CAMK2D protein
calcium/calmodulin-dependent protein kinase (EC 2.7.11.17)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Calcium/calmodulin-dependent protein kinase type II subunit delta
SynonymsCAMKD
hCG_22679
DescriptionFUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program . Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis . May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). .

AccessionsQ13557
ENST00000699372.1
ENST00000699416.1
A0A8V8TPM4
A0A8V8TN60
ENST00000706057.1
E9PBG7
E9PF82
A0A8V8TPY4
ENST00000699378.1
A0A8V8TNA1
A0A994J7X8
H0Y9C2
ENST00000699381.1 [Q13557-6]
A0A8V8TNA7
A0A8V8TPJ8
ENST00000706055.1
ENST00000699374.1
ENST00000699382.1
ENST00000699376.1
A0A8V8TN88
ENST00000515496.5 [Q13557-3]
ENST00000699377.1
ENST00000508738.5 [Q13557-9]
A0A8V8TNN4
ENST00000379773.6 [Q13557-8]
A0A8V8TPK3
ENST00000699418.1
A0A994J516
ENST00000505990.5
A0A8V8TNR6
ENST00000699379.1
ENST00000699373.1
ENST00000699380.1
ENST00000296402.9 [Q13557-8]
A0A8V8TQ10
H0Y9J2
ENST00000699419.1
ENST00000509594.1
ENST00000699047.1 [Q13557-6]
ENST00000513132.5
ENST00000699421.1
D6R938
A0A8V8TND4
ENST00000394522.7 [Q13557-10]
Q4G1A8
A0A994J5B0
ENST00000683023.1 [Q13557-1]
ENST00000699375.1
ENST00000394524.7 [Q13557-12]
ENST00000342666.9 [Q13557-1]
A0A8V8TN65
ENST00000511664.6
ENST00000514328.5
ENST00000706056.1
A0A8V8TNN9
ENST00000699048.1 [Q13557-11]
ENST00000699417.1