BTK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001780Biological processneutrophil homeostasis
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0007498Biological processmesoderm development
GO_0097190Biological processapoptotic signaling pathway
GO_0050766Biological processpositive regulation of phagocytosis
GO_0030167Biological processproteoglycan catabolic process
GO_0034614Biological processcellular response to reactive oxygen species
GO_0061516Biological processmonocyte proliferation
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0019722Biological processcalcium-mediated signaling
GO_0098761Biological processcellular response to interleukin-7
GO_1990959Biological processeosinophil homeostasis
GO_0045087Biological processinnate immune response
GO_0050853Biological processB cell receptor signaling pathway
GO_0002553Biological processhistamine secretion by mast cell
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0002902Biological processregulation of B cell apoptotic process
GO_0001805Biological processpositive regulation of type III hypersensitivity
GO_0032496Biological processresponse to lipopolysaccharide
GO_0050852Biological processT cell receptor signaling pathway
GO_0045579Biological processpositive regulation of B cell differentiation
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0002344Biological processB cell affinity maturation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0002250Biological processadaptive immune response
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0035556Biological processintracellular signal transduction
GO_0150153Biological processpositive regulation of interleukin-17A production
GO_0042113Biological processB cell activation
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0002721Biological processregulation of B cell cytokine production
GO_1901647Biological processpositive regulation of synoviocyte proliferation
GO_0071226Biological processcellular response to molecule of fungal origin
GO_0006468Biological processprotein phosphorylation
GO_0001812Biological processpositive regulation of type I hypersensitivity
GO_0048469Biological processcell maturation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016004Molecular functionphospholipase activator activity
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0043274Molecular functionphospholipase binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBTK
Protein nameTyrosine-protein kinase BTK isoform 51
Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9
Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5
Tyrosine-protein kinase BTK isoform 65
Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 7
Tyrosine-protein kinase BTK isoform (Lacking exon 15 to 18)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
non-specific protein-tyrosine kinase (EC 2.7.10.2)
Bruton tyrosine kinase
Tyrosine-protein kinase BTK isoform (Lacking exon 14)
Bruton tyrosine kinase (Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 8)
Tyrosine-protein kinase BTK isoform (Lacking exon 13 to 17)
Bruton tyrosine kinase (Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4)
Bruton tyrosine kinase (Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10)
Tyrosine-protein kinase BTK isoform 52
Bruton tyrosine kinase (Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 1)
Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6
Tyrosine-protein kinase (EC 2.7.10.2)
Synonymsisoform
9
4
hCG_20400
ATK
BPK
deficient
3
2
6
5
1
8
kinase
AGMX1
7
DescriptionFUNCTION: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling . Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation . After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members . PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK . BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways . Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway . The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense . Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells . Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation . BTK also plays a critical role in transcription regulation . Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes . BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B . Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 . Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR . GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression . ARID3A and NFAT are other transcriptional target of BTK . BTK is required for the formation of functional ARID3A DNA-binding complexes . There is however no evidence that BTK itself binds directly to DNA . BTK has a dual role in the regulation of apoptosis . .

AccessionsQ3MS92
ENST00000695621.1
ENST00000695629.1
Q3MS95
ENST00000695628.1
ENST00000695626.1
ENST00000695625.1
A0A8Q3WKS7
ENST00000470329.1
ENST00000695643.1
Q3MS88
ENST00000695617.1
ENST00000695631.1
Q3MS94
Q3MS97
ENST00000695616.1
Q3MS96
Q3MS93
ENST00000695627.1
A0A8Q3WKR7
ENST00000695623.1
ENST00000695618.1
A0A8Q3SI44
Q572P1
Q572P2
A0A8Q3SHX9
ENST00000703407.1
Q3MS91
ENST00000621635.4 [Q06187-2]
ENST00000695630.1
Q572P5
A0A8Q3WKM0
ENST00000695614.1 [Q06187-1]
ENST00000695622.1
Q5JY90
A0A8Q3WLR2
Q3MS89
Q3MS90
U3NG26
A0A8Q3WLZ5
A0A8Q3WL62
ENST00000695615.1 [Q06187-1]
A0A8Q3WKN1
A0A8Q3SI38
A0A8Q3SI35
Q572P4
A0A8Q3SHZ6
Q572P3
ENST00000695619.1
ENST00000308731.8 [Q06187-1]
ENST00000695620.1
Q572P0
Q06187