Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 52 studies | 48% ± 19% | |
pericyte | 26 studies | 31% ± 20% | |
fibroblast | 22 studies | 36% ± 20% | |
astrocyte | 19 studies | 39% ± 16% | |
smooth muscle cell | 18 studies | 35% ± 19% | |
oligodendrocyte precursor cell | 15 studies | 41% ± 17% | |
capillary endothelial cell | 15 studies | 43% ± 14% | |
vein endothelial cell | 15 studies | 49% ± 19% | |
glutamatergic neuron | 13 studies | 62% ± 23% | |
macrophage | 13 studies | 38% ± 22% | |
endothelial cell of artery | 13 studies | 48% ± 12% | |
microglial cell | 13 studies | 40% ± 13% | |
endothelial cell of vascular tree | 13 studies | 44% ± 24% | |
endothelial cell of lymphatic vessel | 11 studies | 40% ± 22% | |
GABAergic neuron | 11 studies | 58% ± 21% | |
adipocyte | 10 studies | 40% ± 12% | |
epithelial cell | 9 studies | 35% ± 12% | |
basal cell | 9 studies | 36% ± 25% | |
type I pneumocyte | 8 studies | 41% ± 15% | |
neuron | 7 studies | 57% ± 18% | |
interneuron | 7 studies | 62% ± 21% | |
retinal ganglion cell | 7 studies | 56% ± 15% | |
myeloid cell | 7 studies | 24% ± 7% | |
oligodendrocyte | 7 studies | 26% ± 13% | |
ciliated cell | 6 studies | 25% ± 6% | |
club cell | 6 studies | 28% ± 8% | |
retina horizontal cell | 6 studies | 31% ± 14% | |
retinal cone cell | 6 studies | 46% ± 10% | |
dendritic cell | 6 studies | 35% ± 28% | |
monocyte | 6 studies | 41% ± 27% | |
myofibroblast cell | 5 studies | 32% ± 19% | |
amacrine cell | 5 studies | 38% ± 11% | |
cardiac muscle cell | 5 studies | 39% ± 11% | |
mesothelial cell | 5 studies | 28% ± 11% | |
Mueller cell | 5 studies | 30% ± 8% | |
connective tissue cell | 5 studies | 32% ± 12% | |
type II pneumocyte | 5 studies | 29% ± 7% | |
endothelial cell of sinusoid | 4 studies | 34% ± 17% | |
glomerular endothelial cell | 4 studies | 49% ± 6% | |
abnormal cell | 4 studies | 30% ± 17% | |
granule cell | 4 studies | 42% ± 8% | |
retinal bipolar neuron | 4 studies | 27% ± 11% | |
OFF-bipolar cell | 4 studies | 34% ± 12% | |
ON-bipolar cell | 4 studies | 34% ± 11% | |
retinal rod cell | 4 studies | 31% ± 9% | |
mast cell | 4 studies | 43% ± 31% | |
muscle cell | 4 studies | 32% ± 22% | |
GABAergic interneuron | 3 studies | 60% ± 6% | |
glial cell | 3 studies | 32% ± 10% | |
progenitor cell | 3 studies | 41% ± 9% | |
endocardial cell | 3 studies | 52% ± 15% | |
mononuclear phagocyte | 3 studies | 21% ± 6% | |
lymphocyte | 3 studies | 27% ± 9% | |
GABAergic amacrine cell | 3 studies | 49% ± 8% | |
glycinergic amacrine cell | 3 studies | 37% ± 10% | |
rod bipolar cell | 3 studies | 30% ± 9% | |
B cell | 3 studies | 46% ± 38% | |
Schwann cell | 3 studies | 52% ± 23% | |
chondrocyte | 3 studies | 58% ± 29% | |
natural killer cell | 3 studies | 47% ± 37% | |
hepatocyte | 3 studies | 35% ± 13% | |
retinal pigment epithelial cell | 3 studies | 36% ± 23% | |
neural progenitor cell | 3 studies | 41% ± 15% | |
ependymal cell | 3 studies | 41% ± 18% | |
adventitial cell | 3 studies | 23% ± 6% | |
T cell | 3 studies | 24% ± 7% | |
alveolar macrophage | 3 studies | 45% ± 7% | |
respiratory goblet cell | 3 studies | 37% ± 12% | |
mucus secreting cell | 3 studies | 33% ± 4% | |
enteroendocrine cell | 3 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5013.92 | 1445 / 1445 | 100% | 39.11 | 183 / 183 |
lung | 100% | 12993.49 | 578 / 578 | 100% | 28.04 | 1151 / 1155 |
brain | 100% | 4924.09 | 2636 / 2642 | 100% | 36.47 | 704 / 705 |
breast | 100% | 6529.74 | 459 / 459 | 99% | 40.91 | 1111 / 1118 |
prostate | 100% | 5138.50 | 244 / 245 | 99% | 31.50 | 495 / 502 |
ovary | 100% | 4712.07 | 180 / 180 | 98% | 22.50 | 421 / 430 |
thymus | 100% | 5619.91 | 653 / 653 | 98% | 29.34 | 590 / 605 |
bladder | 100% | 6730.33 | 21 / 21 | 96% | 21.04 | 485 / 504 |
uterus | 100% | 6965.00 | 170 / 170 | 96% | 20.88 | 441 / 459 |
kidney | 100% | 3812.30 | 89 / 89 | 96% | 33.79 | 864 / 901 |
skin | 100% | 4889.65 | 1805 / 1809 | 96% | 30.92 | 453 / 472 |
stomach | 99% | 3270.00 | 356 / 359 | 96% | 27.08 | 274 / 286 |
adrenal gland | 100% | 8072.04 | 258 / 258 | 95% | 25.10 | 218 / 230 |
intestine | 100% | 5164.56 | 966 / 966 | 94% | 19.89 | 494 / 527 |
pancreas | 87% | 1556.77 | 285 / 328 | 98% | 32.78 | 175 / 178 |
liver | 94% | 1677.13 | 212 / 226 | 64% | 8.65 | 260 / 406 |
adipose | 100% | 7671.57 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 8811.24 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3335.35 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.72 | 1 / 1 |
muscle | 100% | 2847.43 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 4575.47 | 856 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 20.44 | 42 / 45 |
eye | 0% | 0 | 0 / 0 | 66% | 9.80 | 53 / 80 |
lymph node | 0% | 0 | 0 / 0 | 55% | 7.85 | 16 / 29 |
peripheral blood | 29% | 982.34 | 274 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001974 | Biological process | blood vessel remodeling |
GO_1905314 | Biological process | semi-lunar valve development |
GO_0009267 | Biological process | cellular response to starvation |
GO_0030509 | Biological process | BMP signaling pathway |
GO_0001707 | Biological process | mesoderm formation |
GO_0048738 | Biological process | cardiac muscle tissue development |
GO_0006468 | Biological process | protein phosphorylation |
GO_0045778 | Biological process | positive regulation of ossification |
GO_0048842 | Biological process | positive regulation of axon extension involved in axon guidance |
GO_0003252 | Biological process | negative regulation of cell proliferation involved in heart valve morphogenesis |
GO_0007178 | Biological process | cell surface receptor protein serine/threonine kinase signaling pathway |
GO_0003151 | Biological process | outflow tract morphogenesis |
GO_0071773 | Biological process | cellular response to BMP stimulus |
GO_0003183 | Biological process | mitral valve morphogenesis |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
GO_0072577 | Biological process | endothelial cell apoptotic process |
GO_0060412 | Biological process | ventricular septum morphogenesis |
GO_0001568 | Biological process | blood vessel development |
GO_0045906 | Biological process | negative regulation of vasoconstriction |
GO_0030308 | Biological process | negative regulation of cell growth |
GO_0001893 | Biological process | maternal placenta development |
GO_0003148 | Biological process | outflow tract septum morphogenesis |
GO_0060836 | Biological process | lymphatic endothelial cell differentiation |
GO_0003181 | Biological process | atrioventricular valve morphogenesis |
GO_0001946 | Biological process | lymphangiogenesis |
GO_0071363 | Biological process | cellular response to growth factor stimulus |
GO_0002063 | Biological process | chondrocyte development |
GO_0061298 | Biological process | retina vasculature development in camera-type eye |
GO_0003085 | Biological process | negative regulation of systemic arterial blood pressure |
GO_0003197 | Biological process | endocardial cushion development |
GO_0009952 | Biological process | anterior/posterior pattern specification |
GO_1902731 | Biological process | negative regulation of chondrocyte proliferation |
GO_0060840 | Biological process | artery development |
GO_0003186 | Biological process | tricuspid valve morphogenesis |
GO_0061036 | Biological process | positive regulation of cartilage development |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0010634 | Biological process | positive regulation of epithelial cell migration |
GO_0048286 | Biological process | lung alveolus development |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0032924 | Biological process | activin receptor signaling pathway |
GO_0030166 | Biological process | proteoglycan biosynthetic process |
GO_0060841 | Biological process | venous blood vessel development |
GO_0060173 | Biological process | limb development |
GO_0051148 | Biological process | negative regulation of muscle cell differentiation |
GO_0060413 | Biological process | atrial septum morphogenesis |
GO_0014916 | Biological process | regulation of lung blood pressure |
GO_0060426 | Biological process | lung vasculature development |
GO_0060350 | Biological process | endochondral bone morphogenesis |
GO_0001935 | Biological process | endothelial cell proliferation |
GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
GO_0003176 | Biological process | aortic valve development |
GO_0003177 | Biological process | pulmonary valve development |
GO_0061626 | Biological process | pharyngeal arch artery morphogenesis |
GO_0030501 | Biological process | positive regulation of bone mineralization |
GO_0043025 | Cellular component | neuronal cell body |
GO_0009925 | Cellular component | basal plasma membrane |
GO_0009986 | Cellular component | cell surface |
GO_0005654 | Cellular component | nucleoplasm |
GO_0030425 | Cellular component | dendrite |
GO_0005912 | Cellular component | adherens junction |
GO_0005615 | Cellular component | extracellular space |
GO_0043235 | Cellular component | receptor complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0030424 | Cellular component | axon |
GO_0005901 | Cellular component | caveola |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0016362 | Molecular function | activin receptor activity, type II |
GO_0005524 | Molecular function | ATP binding |
GO_0098821 | Molecular function | BMP receptor activity |
GO_0046872 | Molecular function | metal ion binding |
GO_1990782 | Molecular function | protein tyrosine kinase binding |
GO_0036122 | Molecular function | BMP binding |
GO_0005515 | Molecular function | protein binding |
GO_0045296 | Molecular function | cadherin binding |
GO_0019838 | Molecular function | growth factor binding |
GO_0005024 | Molecular function | transforming growth factor beta receptor activity |
Gene name | BMPR2 |
Protein name | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) |
Synonyms | PPH1 |
Description | FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade . Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. . |
Accessions | ENST00000374574.2 [Q13873-2] ENST00000374580.10 [Q13873-1] Q13873 |