BCCIP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	10 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	20% ± 5%	Explore
memory B cell	9 studies	18% ± 3%	Explore
ciliated cell	8 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	8 studies	21% ± 8%	Explore
mucosal invariant T cell	8 studies	18% ± 3%	Explore
naive B cell	8 studies	19% ± 2%	Explore
epithelial cell	8 studies	29% ± 14%	Explore
B cell	8 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	18% ± 2%	Explore
endothelial cell	7 studies	22% ± 4%	Explore
regulatory T cell	7 studies	20% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	20% ± 2%	Explore
basal cell	6 studies	21% ± 6%	Explore
gamma-delta T cell	6 studies	23% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	17% ± 2%	Explore
erythroblast	5 studies	29% ± 12%	Explore
oligodendrocyte precursor cell	5 studies	26% ± 5%	Explore
plasmablast	4 studies	41% ± 20%	Explore
non-classical monocyte	4 studies	23% ± 7%	Explore
abnormal cell	4 studies	25% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
astrocyte	4 studies	21% ± 4%	Explore
interneuron	4 studies	24% ± 13%	Explore
oligodendrocyte	4 studies	19% ± 2%	Explore
plasmacytoid dendritic cell	4 studies	25% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 3%	Explore
mature NK T cell	4 studies	16% ± 1%	Explore
hematopoietic precursor cell	3 studies	22% ± 6%	Explore
classical monocyte	3 studies	22% ± 2%	Explore
fibroblast	3 studies	26% ± 2%	Explore
myofibroblast cell	3 studies	19% ± 2%	Explore
precursor B cell	3 studies	20% ± 3%	Explore
respiratory goblet cell	3 studies	28% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
macrophage	3 studies	19% ± 3%	Explore
GABAergic neuron	3 studies	31% ± 4%	Explore
glutamatergic neuron	3 studies	39% ± 10%	Explore
dendritic cell	3 studies	33% ± 11%	Explore
intestinal crypt stem cell	3 studies	18% ± 2%	Explore
erythrocyte	3 studies	36% ± 13%	Explore
double negative thymocyte	3 studies	27% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	18% ± 2%	Explore
brain	6 studies	27% ± 8%	Explore
lung	3 studies	18% ± 1%	Explore
eye	3 studies	20% ± 5%	Explore
liver	3 studies	32% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2167.62	459 / 459	100%	46.06	1118 / 1118
esophagus	100%	1907.98	1445 / 1445	100%	30.44	183 / 183
liver	100%	1439.59	226 / 226	100%	25.53	406 / 406
ovary	100%	2532.67	180 / 180	100%	31.24	430 / 430
prostate	100%	2320.57	245 / 245	100%	44.80	502 / 502
stomach	100%	1919.87	359 / 359	100%	31.76	286 / 286
brain	100%	1831.13	2640 / 2642	100%	35.73	705 / 705
lung	100%	1711.23	577 / 578	100%	34.22	1155 / 1155
intestine	100%	2049.17	966 / 966	100%	33.36	526 / 527
bladder	100%	2113.48	21 / 21	100%	35.02	503 / 504
uterus	100%	2063.09	170 / 170	100%	42.60	458 / 459
pancreas	100%	1316.62	327 / 328	100%	26.39	178 / 178
thymus	100%	2145.92	653 / 653	100%	34.65	603 / 605
kidney	100%	2166.70	89 / 89	100%	26.88	897 / 901
adrenal gland	100%	1920.29	258 / 258	98%	22.74	226 / 230
skin	100%	2181.54	1809 / 1809	97%	24.65	456 / 472
adipose	100%	2080.30	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	42.66	29 / 29
muscle	100%	2536.90	803 / 803	0%	0	0 / 0
spleen	100%	1837.81	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	35.50	45 / 45
ureter	0%	0	0 / 0	100%	24.51	1 / 1
blood vessel	100%	1994.33	1334 / 1335	0%	0	0 / 0
heart	98%	1670.72	843 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	19.12	75 / 80
peripheral blood	73%	1281.80	680 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0090307	Biological process	mitotic spindle assembly
GO_0061101	Biological process	neuroendocrine cell differentiation
GO_0006281	Biological process	DNA repair
GO_0034453	Biological process	microtubule anchoring
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0007052	Biological process	mitotic spindle organization
GO_0005814	Cellular component	centriole
GO_0005813	Cellular component	centrosome
GO_0097431	Cellular component	mitotic spindle pole
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0019908	Cellular component	nuclear cyclin-dependent protein kinase holoenzyme complex
GO_0005634	Cellular component	nucleus
GO_0019207	Molecular function	kinase regulator activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	BCCIP
Protein name	BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1)
Synonyms	TOK1
Description	FUNCTION: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole . Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta . May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). .
Accessions	ENST00000368759.5 [Q9P287-2] ENST00000299130.7 [Q9P287-4] Q9P287 ENST00000278100.11 [Q9P287-1]

BCCIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review