AZIN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	21 studies	22% ± 5%	Explore
ciliated cell	18 studies	43% ± 15%	Explore
endothelial cell	14 studies	23% ± 6%	Explore
classical monocyte	11 studies	24% ± 8%	Explore
astrocyte	11 studies	27% ± 8%	Explore
monocyte	10 studies	22% ± 7%	Explore
non-classical monocyte	9 studies	23% ± 8%	Explore
glutamatergic neuron	9 studies	32% ± 20%	Explore
plasmacytoid dendritic cell	9 studies	24% ± 7%	Explore
fibroblast	9 studies	22% ± 5%	Explore
mast cell	8 studies	20% ± 4%	Explore
regulatory T cell	8 studies	18% ± 3%	Explore
natural killer cell	7 studies	21% ± 4%	Explore
epithelial cell	7 studies	39% ± 19%	Explore
oligodendrocyte precursor cell	7 studies	23% ± 8%	Explore
B cell	6 studies	20% ± 4%	Explore
endothelial cell of artery	6 studies	20% ± 3%	Explore
myeloid cell	6 studies	28% ± 9%	Explore
plasma cell	6 studies	22% ± 9%	Explore
basal cell	6 studies	29% ± 9%	Explore
CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
GABAergic neuron	6 studies	33% ± 14%	Explore
gamma-delta T cell	6 studies	24% ± 9%	Explore
T cell	5 studies	27% ± 15%	Explore
mononuclear phagocyte	5 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
conventional dendritic cell	5 studies	27% ± 8%	Explore
neuron	5 studies	38% ± 13%	Explore
naive B cell	5 studies	18% ± 4%	Explore
abnormal cell	5 studies	25% ± 10%	Explore
interneuron	5 studies	31% ± 18%	Explore
plasmablast	4 studies	27% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	20% ± 2%	Explore
memory B cell	4 studies	17% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	20% ± 2%	Explore
T follicular helper cell	4 studies	18% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	20% ± 3%	Explore
adipocyte	4 studies	22% ± 5%	Explore
goblet cell	4 studies	27% ± 9%	Explore
leukocyte	4 studies	25% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 3%	Explore
oligodendrocyte	4 studies	22% ± 4%	Explore
hematopoietic precursor cell	3 studies	26% ± 5%	Explore
microglial cell	3 studies	20% ± 3%	Explore
placental villous trophoblast	3 studies	37% ± 19%	Explore
mucosal invariant T cell	3 studies	22% ± 2%	Explore
precursor B cell	3 studies	18% ± 1%	Explore
retinal pigment epithelial cell	3 studies	27% ± 8%	Explore
tissue-resident macrophage	3 studies	19% ± 4%	Explore
Mueller cell	3 studies	24% ± 5%	Explore
secretory cell	3 studies	20% ± 4%	Explore
mesothelial cell	3 studies	27% ± 6%	Explore
granulocyte	3 studies	22% ± 1%	Explore
neutrophil	3 studies	22% ± 8%	Explore
enteroendocrine cell	3 studies	25% ± 11%	Explore
pericyte	3 studies	18% ± 2%	Explore
transit amplifying cell	3 studies	26% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 5%	Explore
mature NK T cell	3 studies	16% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	29% ± 13%	Explore
lung	7 studies	26% ± 6%	Explore
peripheral blood	5 studies	21% ± 4%	Explore
eye	4 studies	24% ± 6%	Explore
intestine	3 studies	24% ± 7%	Explore
liver	3 studies	33% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5224.98	1444 / 1445	100%	108.83	183 / 183
breast	100%	6249.22	459 / 459	100%	169.28	1117 / 1118
brain	100%	6807.74	2639 / 2642	100%	138.88	705 / 705
lung	100%	5632.39	577 / 578	100%	118.16	1155 / 1155
prostate	100%	5558.23	245 / 245	100%	111.54	500 / 502
ovary	100%	4999.88	180 / 180	100%	92.18	428 / 430
pancreas	100%	7526.24	328 / 328	99%	87.52	177 / 178
stomach	100%	4869.86	359 / 359	99%	105.46	284 / 286
bladder	100%	7300.33	21 / 21	99%	106.13	500 / 504
intestine	100%	5891.19	966 / 966	99%	109.83	520 / 527
thymus	100%	5611.66	653 / 653	99%	81.75	596 / 605
uterus	100%	4731.70	170 / 170	98%	90.48	452 / 459
adrenal gland	100%	6450.30	258 / 258	97%	68.68	222 / 230
skin	100%	5776.82	1807 / 1809	96%	103.68	451 / 472
liver	100%	3801.25	226 / 226	94%	63.49	382 / 406
kidney	100%	3992.53	89 / 89	91%	50.88	822 / 901
blood vessel	100%	5769.86	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	85.48	29 / 29
spleen	100%	3714.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	80.70	45 / 45
ureter	0%	0	0 / 0	100%	62.10	1 / 1
adipose	100%	7064.96	1203 / 1204	0%	0	0 / 0
muscle	100%	3452.12	800 / 803	0%	0	0 / 0
peripheral blood	95%	6131.52	882 / 929	0%	0	0 / 0
heart	94%	3697.76	812 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	64.76	67 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042177	Biological process	negative regulation of protein catabolic process
GO_1902269	Biological process	positive regulation of polyamine transmembrane transport
GO_0033387	Biological process	putrescine biosynthetic process from ornithine
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004586	Molecular function	ornithine decarboxylase activity
GO_0042978	Molecular function	ornithine decarboxylase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	AZIN1
Protein name	Antizyme inhibitor 1 Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor)
Synonyms	OAZI OAZIN
Description	FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding . Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production . .
Accessions	ENST00000683965.1 A0A804HLH4 ENST00000521536.6 ENST00000683787.1 U3KQI8 E5RIB7 O14977 ENST00000347770.8 A0A804HIJ4 ENST00000682014.1 ENST00000337198.10 ENST00000682969.1 ENST00000682725.1 ENST00000520402.5 ENST00000684459.1 ENST00000681985.1 E5RJ16 ENST00000684721.1 A0A804HKI3 ENST00000684566.1 A0A804HKE3 ENST00000518353.5

AZIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review