ATG3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0000045Biological processautophagosome assembly
GO_0006612Biological processprotein targeting to membrane
GO_1902017Biological processregulation of cilium assembly
GO_0043653Biological processmitochondrial fragmentation involved in apoptotic process
GO_0050765Biological processnegative regulation of phagocytosis
GO_0000422Biological processautophagy of mitochondrion
GO_0015031Biological processprotein transport
GO_0061723Biological processglycophagy
GO_0044804Biological processnucleophagy
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0034274Cellular componentAtg12-Atg5-Atg16 complex
GO_0019899Molecular functionenzyme binding
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0019777Molecular functionAtg12 transferase activity
GO_0141046Molecular functionAtg8-family conjugating enzyme activity
GO_0019776Molecular functionAtg8-family ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATG3
Protein nameUbiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)
Autophagy related 3
SynonymsAPG3
APG3L
DescriptionFUNCTION: E2 conjugating enzyme that catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation . Cycles back and forth between binding to ATG7 for loading with the ATG8-like proteins and binding to E3 enzyme, composed of ATG12, ATG5 and ATG16L1 to promote ATG8-like proteins lipidation . Also plays a role as a membrane curvature sensor that facilitates LC3/GABARAP lipidation by sensing local membrane stress associated with lipid-packing defects as occurs with high molar proportions of conical lipids or strident membrane curvature (By similarity). Interacts with negatively-charged membranes promoting membrane tethering and enhancing LC3/GABARAP lipidation . Also acts as an autocatalytic E2-like enzyme by catalyzing the conjugation of ATG12 to itself in an ATG7-dependent manner, this complex thus formed, plays a role in mitochondrial homeostasis but not in autophagy (By similarity). ATG12-ATG3 conjugation promotes late endosome to lysosome trafficking and basal autophagosome maturation via its interaction with PDCD6IP (By similarity). ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation (By similarity). Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity). .

AccessionsF8WDI0
ENST00000496423.1
ENST00000283290.10 [Q9NT62-1]
ENST00000402314.6 [Q9NT62-2]
Q9NT62