ZDHHC17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0043067Biological processregulation of programmed cell death
GO_0007409Biological processaxonogenesis
GO_0051386Biological processregulation of neurotrophin TRK receptor signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042953Biological processlipoprotein transport
GO_0018345Biological processprotein palmitoylation
GO_0005794Cellular componentGolgi apparatus
GO_0042734Cellular componentpresynaptic membrane
GO_0000139Cellular componentGolgi membrane
GO_0042995Cellular componentcell projection
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030660Cellular componentGolgi-associated vesicle membrane
GO_0019705Molecular functionprotein-cysteine S-myristoyltransferase activity
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0140439Molecular functionprotein-cysteine S-stearoyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZDHHC17
Protein namePalmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17)
Zinc finger DHHC-type palmitoyltransferase 17
SynonymsKIAA0946
HIP14
HSPC294
HIP3
HYPH
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes . Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT . Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 . Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane . May play a role in Mg(2+) transport . Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation . .

AccessionsF8VPW2
ENST00000547620.5
H0YHW0
H0YIK0
ENST00000551407.5
ENST00000426126.7 [Q8IUH5-1]
F8VUG7
ENST00000550876.1
ENST00000546778.5
H0YHF0
ENST00000547604.1
H0YIP7
ENST00000549682.5
H0YI74
Q8IUH5
ENST00000552453.5
ENST00000550163.5
H0YIN1
ENST00000549944.1
F8VX48