Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 29% ± 12% | |
plasmacytoid dendritic cell | 12 studies | 34% ± 9% | |
glutamatergic neuron | 11 studies | 41% ± 26% | |
astrocyte | 11 studies | 35% ± 16% | |
oligodendrocyte | 11 studies | 31% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 29% ± 14% | |
GABAergic neuron | 9 studies | 41% ± 22% | |
endothelial cell of lymphatic vessel | 8 studies | 36% ± 16% | |
neuron | 6 studies | 29% ± 13% | |
interneuron | 6 studies | 44% ± 24% | |
macrophage | 6 studies | 29% ± 7% | |
microglial cell | 6 studies | 27% ± 6% | |
adipocyte | 6 studies | 24% ± 5% | |
fibroblast | 6 studies | 25% ± 8% | |
dendritic cell | 6 studies | 28% ± 14% | |
granule cell | 4 studies | 23% ± 5% | |
epithelial cell | 4 studies | 22% ± 6% | |
retinal bipolar neuron | 4 studies | 17% ± 1% | |
pericyte | 4 studies | 26% ± 9% | |
smooth muscle cell | 4 studies | 22% ± 1% | |
GABAergic interneuron | 3 studies | 27% ± 4% | |
retinal ganglion cell | 3 studies | 26% ± 1% | |
amacrine cell | 3 studies | 21% ± 4% | |
cardiac muscle cell | 3 studies | 17% ± 1% | |
mast cell | 3 studies | 19% ± 2% | |
ON-bipolar cell | 3 studies | 27% ± 9% | |
glycinergic amacrine cell | 3 studies | 19% ± 4% | |
retina horizontal cell | 3 studies | 22% ± 7% | |
retinal rod cell | 3 studies | 19% ± 2% | |
ependymal cell | 3 studies | 45% ± 15% | |
monocyte | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4240.95 | 2641 / 2642 | 100% | 29.52 | 705 / 705 |
adrenal gland | 100% | 2674.77 | 258 / 258 | 100% | 16.62 | 229 / 230 |
esophagus | 100% | 2569.36 | 1442 / 1445 | 99% | 10.21 | 182 / 183 |
breast | 100% | 4081.54 | 459 / 459 | 99% | 13.67 | 1107 / 1118 |
thymus | 100% | 3713.53 | 653 / 653 | 99% | 14.64 | 598 / 605 |
prostate | 100% | 3030.53 | 245 / 245 | 99% | 12.01 | 496 / 502 |
lung | 100% | 2909.20 | 577 / 578 | 99% | 10.51 | 1139 / 1155 |
pancreas | 100% | 1649.79 | 327 / 328 | 97% | 10.14 | 173 / 178 |
uterus | 100% | 4850.51 | 170 / 170 | 97% | 9.83 | 444 / 459 |
kidney | 100% | 1932.91 | 89 / 89 | 96% | 12.80 | 866 / 901 |
bladder | 100% | 3425.52 | 21 / 21 | 95% | 8.56 | 477 / 504 |
stomach | 100% | 2017.60 | 358 / 359 | 91% | 7.84 | 261 / 286 |
skin | 100% | 2126.85 | 1806 / 1809 | 91% | 10.65 | 429 / 472 |
ovary | 100% | 4605.77 | 180 / 180 | 90% | 6.18 | 385 / 430 |
intestine | 100% | 3229.27 | 966 / 966 | 89% | 6.79 | 470 / 527 |
liver | 100% | 1107.50 | 226 / 226 | 72% | 4.71 | 292 / 406 |
blood vessel | 100% | 3307.95 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3167.97 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.84 | 1 / 1 |
adipose | 100% | 3941.79 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 1939.53 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 1798.82 | 853 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 7.32 | 42 / 45 |
peripheral blood | 82% | 1473.65 | 759 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 79% | 7.35 | 23 / 29 |
eye | 0% | 0 | 0 / 0 | 61% | 6.15 | 49 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
GO_0043067 | Biological process | regulation of programmed cell death |
GO_0007409 | Biological process | axonogenesis |
GO_0051386 | Biological process | regulation of neurotrophin TRK receptor signaling pathway |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0042953 | Biological process | lipoprotein transport |
GO_0018345 | Biological process | protein palmitoylation |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0042734 | Cellular component | presynaptic membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0042995 | Cellular component | cell projection |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0030660 | Cellular component | Golgi-associated vesicle membrane |
GO_0019705 | Molecular function | protein-cysteine S-myristoyltransferase activity |
GO_0016409 | Molecular function | palmitoyltransferase activity |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0019706 | Molecular function | protein-cysteine S-palmitoyltransferase activity |
GO_0140439 | Molecular function | protein-cysteine S-stearoyltransferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ZDHHC17 |
Protein name | Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) Zinc finger DHHC-type palmitoyltransferase 17 |
Synonyms | KIAA0946 HIP14 HSPC294 HIP3 HYPH |
Description | FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes . Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT . Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 . Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane . May play a role in Mg(2+) transport . Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation . . |
Accessions | F8VPW2 ENST00000547620.5 H0YHW0 H0YIK0 ENST00000551407.5 ENST00000426126.7 [Q8IUH5-1] F8VUG7 ENST00000550876.1 ENST00000546778.5 H0YHF0 ENST00000547604.1 H0YIP7 ENST00000549682.5 H0YI74 Q8IUH5 ENST00000552453.5 ENST00000550163.5 H0YIN1 ENST00000549944.1 F8VX48 |