WDR82 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0110064Biological processlncRNA catabolic process
GO_0006353Biological processDNA-templated transcription termination
GO_0032785Biological processnegative regulation of DNA-templated transcription, elongation
GO_0071027Biological processnuclear RNA surveillance
GO_0140744Biological processnegative regulation of lncRNA transcription
GO_0048188Cellular componentSet1C/COMPASS complex
GO_0005730Cellular componentnucleolus
GO_0072357Cellular componentPTW/PP1 phosphatase complex
GO_0035097Cellular componenthistone methyltransferase complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameWDR82
Protein nameWD repeat domain 82
WD repeat-containing protein 82
SynonymsTMEM113
SWD2
UNQ9342/PRO34047
WDR82A
DescriptionFUNCTION: Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes . Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) . Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase . Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) . The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome . .

AccessionsENST00000296490.8
ENST00000469000.5
C9JBU3
C9J355
Q6UXN9
ENST00000463624.1