WDFY2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031982Cellular componentvesicle
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameWDFY2
Protein nameWD repeat and FYVE domain containing 2
WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22)
SynonymsZFYVE22
WDF2
DescriptionFUNCTION: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 . Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 . Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis . .

AccessionsENST00000612477.1
ENST00000298125.7
A0A087WZX3
Q96P53